Microsoft word - tees community infection guidance sept 2010.doc
Community Infection Guidance Aims • To provide a simple, best guess approach to the treatment of common infections
• To promote the safe, effective and economic use of antibiotics
• To minimise the emergence of bacterial resistance in the community
Principles of Treatment 1. This guidance is based on the best available evidence but its application must be modified by clinical judgement
and taking patient specific factors into consideration, e.g. renal / hepatic function, allergies etc.
2. Prescribe by generic name; all treatments are oral unless otherwise stated. 3. A dose and duration of treatment is suggested. In severe or recurrent cases consider a larger dose or longer
course. Doses are for adults unless otherwise stated
4. Prescribe an antibiotic only when there is likely to be a clear clinical benefit. 5. Do not prescribe an antibiotic for viral sore throat or simple coughs and colds. 6. Limit prescribing over the telephone to exceptional cases. 7. Avoid broad spectrum antibiotics (e.g. co-amoxiclav, quinolones and cephalosporins) when first line antibiotics
remain effective, as they increase the risk of Clostridium difficile, MRSA and resistant UTIs.
8. Avoid widespread use of topical antibiotics (especially those agents also available as systemic preparations). 9. In pregnancy AVOID tetracyclines, aminoglycosides, quinolones and high dose metronidazole. Short-term use of
trimethoprim (folate antagonist, theoretical risk in first trimester in patients with poor diet) or nitrofurantoin (at term, theoretical risk of neonatal haemolysis) is unlikely to cause problems to the foetus.
10. Some antibiotics may reduce the efficacy of oral and transdermal hormonal contraception. General advice is to use
additional methods of barrier contraception whilst taking the antibiotic and for an extra seven days afterwards. If the seven days runs beyond the end of the pack start a new pack immediately, without a break.
11. Where a ‘best guess’ therapy has failed or special circumstances exist, specialist advice can be obtained from local
consultant microbiologists at JCUH on 01642 282604 or via switchboard/bleep at UHNT/UHH on 01642 617617. UPPER RESPIRATORY TRACT INFECTIONS
Refer to: NICE Clinical Guideline 69, Respiratory Tract Infections – antibiotic prescribing, July 2008 Sore Throat /
• Majority are viral and do not benefit When antibiotics are needed: Pharyngitis / from antibiotics. Consider non- or First line: Tonsillitis
• Consider immediate prescription if 3 or
more Centor criteria, systemically unwell
If allergic to penicillin:
• Clarithromycin 250-500mg twice daily
• Explain normal duration of symptoms –
may take 8 days to resolve; antibiotics only shorten by 8 hours.
Otitis media
• 80% resolve over 4 days without When antibiotics are needed: antibiotics. Consider non- or delayed First line:
• Amoxicillin <2 yrs: 125mg three times daily
• Unilateral pain in children >1 year should 2-10yrs: 250mg three times daily
not routinely require antibiotic treatment.
If allergic to penicillin:
• Erythromycin <2 yrs: 125mg four times daily
• Antibiotics do not reduce pain in first 24
• Use regular paracetamol or ibuprofen for
2nd line: co-amoxiclav if penicillin-allergic: azithromycin for dosesOtitis externa
• Use regular paracetamol or ibuprofen for
If infection present: Topical treatment:
• Use thorough cleansing +/- topical acetic
• Locorten-Vioform ear drops, 2-3 drops twice
Systemic treatment:
• Prescribe oral antibiotics if there are
signs of systemic infection, or if infection
Flucloxacillin 250-500mg four times daily
• Consider fungal infection in resistant
• Clarithromycin 250-500mg twice daily
Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance UPPER RESPIRATORY TRACT INFECTIONS (continued) Rhinosinusitis
• Many are viral. Symptomatic benefit of When antibiotics are needed: antibiotics is small First line options:
• Amoxicillin 500mg three times daily, or
• Doxycycline 200mg stat then 100mg daily
• Reserve antibiotics for severe unilateral /
Treatment failure / persistent symptoms:
• Co-amoxiclav 625mg three times daily, or
• If failure to respond use another first line
• Clarithromycin 500mg twice daily (if penicil in allergic)
If allergic to penicillin and pregnant: LOWER RESPIRATORY TRACT INFECTIONS
• Avoid tetracyclines in pregnancy and children under 12 years of age.
• Low doses of penicillins are more likely to select out resistance - use amoxicillin 500mg.
• Quinolones (e.g. ciprofloxacin) have poor activity vs. pneumococci; but do have a use in PROVEN pseudomonad infections
• Antibiotics are not indicated for When antibiotics are needed: Bronchitis First line options:
• Immediate prescription indicated for >65
years with 2 risk factors or >80 years
• Doxycycline 200mg stat then 100mg daily
congestive heart failure, oral steroids)
General Advice:
irrespective of whether or not antibiotics are given.
• Smokers should be encouraged to stop
• Antibiotics only needed if: When antibiotics are needed: exacerbation First line options:
• Amoxicillin 500mg three times daily, or
Doxycycline 200mg stat then 100mg daily
If antibiotics are needed and patient allergic to penicillin and clinical Second Line: failure to doxycycline: use
• Doxycycline 200mg stat then 100mg daily
clarithromycin (see BNF) but reserve for
• Co-amoxiclav 625mg three times daily
Community First Line: Acquired
• Amoxicillin 500mg-1g three times daily
Pneumonia Otherwise, start antibiotics If allergic to penicillin: immediately. If no response in 48 hours
clarithromycin (1st) or a tetracycline to
Second line:
• Co-amoxiclav 625mg three times daily, or
• Bronchiectasis – antibiotic choice should
• Doxycycline 200mg stat then 100mg daily
MENINGITIS Suspected
• Transfer all patients to hospital Meningococcal immediately
admission unless definite history of penicillin anaphylaxis (
NOT allergy).
intramuscular (IM) if a vein cannot be found.
Prevention of
Only prescribe following advice from the
Contact telephone number, 9am – 5pm: 0191 2023888 secondary case
Out of hours – contact on-call HPU practitioner via NEAS on:
of meningitis 0191 4144844 Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance URINARY TRACT INFECTIONS
• Amoxicillin resistance is common, therefore only use if culture confirms sensitivity. • In the elderly (over 65 years) do not treat asymptomatic bacteriuria - it occurs in 25% of women and 10% of men and is not
• In the presence of a catheter, antibiotics will not eradicate bacteriuria; only treat if systemical y unwel or pyelonephritis likely. • Consider sexually transmitted infections as a cause of cystitis in appropriate patients. • Community multi-resistant E. coli with ESBLs (extended-spectrum Beta-lactamase enzymes) are increasing so perform
culture in all treatment failures. ESBL-coliforms are multi-resistant but remain sensitive to nitrofurantoin or fosfomycin (unlicensed – seek further advice from microbiologist or Consultant in Infectious Disease).
Uncomplicated First line options: UTI in women
• Nitrofurantoin 50-100mg four times daily
Treatment failure (second line): according to culture & sensitivities of isolates Recurrent UTI
• Post coital prophylaxis is as effective
First line options: UTI in Men First line options:
• Nitrofurantoin 50-100 mg four times daily
Treatment failure (second line): according to
test is negative for nitrite and positive for leukocyte.
First line options: Pregnancy
• Nitrofurantoin 50mg four times daily
• Avoid nitrofurantoin near-term (risk of
Cystitis / Under 3 months old: Admit to hospital (as per Newcastle Guidelines 2008) Lower UTI in Children Over 3 months old: First line: Alternative: First line options: Pyelonephritis/ Upper UTI
• Admit all children to hospital
• Co-amoxiclav 625mg three times daily
GENITAL TRACT INFECTIONS
• Refer patients with risk factors for STIs to community CASH service or hospital GUM clinic for treatment and contact tracing. • Group B Streptococcus is a common vaginal commensal and does not require treatment except during labour to prevent neonatal
• Clotrimazole 500mg pessary. Insert one pessary
Candidiasis
• Topical and oral products are equally
• Clotrimazole 10% cream. Insert one 5g
applicator full into the vagina at night as a single
Avoid oral antifungal drugs if pregnant or breastfeeding
• Advise patient to not use applicator if
If patient pregnant:
• Clotrimazole 100mg pessary insert one pessary
Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance GENITAL TRACT INFECTIONS (continued) Bacterial
• Treat pregnant women with First line: Vaginosis asymptomatic bacterial vaginosis.
Seek prompt advice from an obstetrician for women with history of If compliance likely to be a problem: If patient pregnant:
• If woman not pregnant, only treat if
• Clindamycin 2% cream insert one 5g applicator
If breast feeding:
• Metronidazole 0.75% gel insert one 5g applicator
Chlamydia First line: trachomatis
• Advise abstinence until all contacts
• Azithromycin 1g single dose, 1 hour before or 2
hours after food. (Sexual abstinence for the
Second line: If patient pregnant:
• Erythromycin 500mg twice daily (repeat swabs to
check cure, 5 weeks after finishing the course)
Trichomoniasis First line: If patient pregnant: Uncomplicated First Line: Gonorrhoea
• Essential to test for N. gonorrhoeaInflammatory
• Metronidazole 400mg twice daily
• Treat after collection of urine for C&S
Prostatitis
• Refer for full GU screen if <35 years
Balanitis
• Treat according to age of patient and
Candidal balanitis (all ages):
• Clotrimazole 1% cream, apply twice daily, or
• Fluconazole 150mg single dose (>16 years only)
Gardnerella-associated balanitis (in adults): Streptococcal balanitis (in adults):
• Amoxicillin 500mg four times dailyBacterial balanitis (in children - see BNF for
• Clarithromycin or erythromycin (if penicillin-allergic)Epididymo-
Refer to Clinical Knowledge Summaries for guidance on assessment and management:
orchitis
http://www.cks.nhs.uk/scrotal_swellings/background_information/causes/epididymo_orchitis#-404534
Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance SKIN & SOFT TISSUE INFECTIONS
Send swabs for culture in al cases if clinically appropriate.
Impetigo
• Patients are infectious until lesions
First line:
• Flucloxacillin 500mg four times daily
If allergic to penicillin: Adults & children able to take tablets:
• Reserve topical antibiotics for very
Children & adults requiring liquid formulation: Very localised lesions:
• Fusidic acid topically four times daily
Using topical antibiotics or adding them to steroids in eczema management encourages resistance and does not improve healing. In infected eczema, use antiseptic bath additives (e.g. Dermol-600, Oilatum Plus) and treat with systemic antibiotics as for impetigo if clinically indicated. First-line: Second-line:
• Malathion 0.5% aqueous liquid x 200ml
Cellulitis
• If patient afebrile and healthy First line: other than cellulitis, flucloxacillin
• Flucloxacillin 500 mg four times daily
may be used as single drug treatment.
• Phenoxymethylpenicllin 500mg four times daily
If allergic to penicillin:
• In facial cellulitis use co-amoxiclav
2nd line (poor response to above after 48 hours): If facial involvement:
• Co-amoxiclav 500/125mg three times daily
If cellulitis has been caused by trauma or wound
consider referral to specialist service. exposed to salt or fresh (not tap) water –seek microbiology or ID advice re. appropriate antibiotic treatment Leg Ulcers
Bacteria will always be present. Antibiotics do not improve healing. Culture swabs and antibiotics are only indicated if there is evidence of clinical infection such as inflammation/redness/cellulitis, increased pain, purulent exudate, rapid deterioration of ulcer or pyrexia. Diabetic Leg or First line: Foot Ulcer / immediately (less than 24 hrs) for
• Flucloxacillin 500mg four times daily
Wound infection
specialist opinion if ANY signs of
• Metronidazole 400mg three times daily
• Take swab for culture and sensitivity
If allergic to penicillin:
• Clarithromycin 500mg twice daily (+metronidazole)
Animal Bite First line:
• Co-amoxiclav 375-625mg three times daily
• Antibiotic prophylaxis advised for –
If allergic to penicillin:
• Metronidazole 400mg three times daily
• Doxycycline 200mg stat then 100mg twice daily
immunocompromised, diabetics, elderly, asplenic
Human Bite First line:
• Assess HIV / hepatitis B & C risk
• Co-amoxiclav 375-625 mg three times daily
If allergic to penicillin:
• Metronidazole 400mg three times daily
• Clarithromycin 250–500mg twice daily
Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance SKIN & SOFT TISSUE INFECTIONS – continued Conjunctivitis When antibiotic treatment is needed: First line:
• Chloramphenicol 0.5% drops one drop every 2
hours (waking hours) for 2 days then reduce to
• Essential eyelid hygiene is priority
• Chloramphenicol 1% ointment; put a small
amount into the affected eye(s) four times a day
Second Line:
• Fusidic acid 1% eye drops one drop into the
Blepharitis
• Essential eyelid hygiene is priority
First line:
• Chloramphenicol 1% ointment apply once daily
N.B. do not use chloramphenicol during third trimester of pregnancy – consult microbiologist for
• Artificial tears can provide symptom
• If persistent or severe, swab eyelid
margin for culture & sensitivities before starting oral treatment
Head Lice
• All regular household contacts should Treatment Options:
• Wet Combing:
Thoroughly comb wet, conditioner-covered hair
with detection comb for 30 minutes, twice weekly
• Insecticides:
Malathion 0.5% aqueous liquid x 50ml. Apply from
root to tip, allow to dry natural y and rinse off after
12 hours. Repeat after 7 days (plus wet combing
• Dimeticone (suitable for people with asthma)
Dimeticone 4% lotion x 50ml. Apply to dry hair
from roots to tips. Leave to dry naturally. Wash off
after 8 hours. Repeat after 7 days (plus wet combing as above)
Dermatophyte
• For children seek advice For superficial or early infection: infection of
• Amorolfine 5% nail lacquer, apply twice a week x
fingernail or
6 months for fingernails; 9-12 months for toenails
For more severe infection:
• Terbinafine 250mg daily (prescribe generically)
x 6 weeks for fingernails, 12 weeks for toenails
Yeast and NON
• For children seek advice For superficial or early infection: dermatophyte
• Amorolfine 5% nail lacquer, apply twice a week
infection of
x 6 months for fingernails; 9-12 months for
fingernail or For more severe nail disease:
improve in appearance despite adequate treatment
• Itraconazole 200mg twice daily for 7 days,
Dermatophyte Localised lesions: infection of the
• Miconazole 2% cream applied twice daily
2nd line (adults only):
• Terbinafine 1% cream applied twice daily
Multiple / intractable lesions / lesions on palms or soles: Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance SKIN & SOFT TISSUE INFECTIONS – continued Pityriasis
• Ketoconazole 2% shampoo applied once daily;
versicolor (endorse prescriptions ‘SLS’)
• For resistant or widespread infection,
For resistant / widespread infection: Varicella Zoster
• Seek specialist advice if:
• Aciclovir 800mg five times a day(Chicken Pox)
- pregnant
- immunocompromised -
- severe infection Valaciclovir may be considered for severe infection in immunocompromised patients (on specialist advice), but
• Antivirals are only of clinical value if
is unlicensed for this indication and 10x the cost of Famciclovir – unlicensed for this indication and up to 50x the cost of aciclovir. Prescribe only on specialist advice. Herpes Zoster
• If pregnant seek specialist advice
• Aciclovir 800mg five times a day(Shingles) Valaciclovir may be considered for severe infection in immunocompromised patients (on specialist advice), but Famciclovir – up to 50x the cost of aciclovir. Prescribe
• Antivirals are only of clinical value if
started within 72 hours of onset of rash
Mild disease (comedonal):
• Benzoyl peroxide 5-10% gel, applied 1-2 times
daily after washing; start with lower strength
• Treat with oral antibiotics for at least
• Tretinoin 0.01-0.025% gel, applied 1-2 times
Mild disease (inflammatory):
• Contraception – women who are Moderate inflammatory disease): Avoid in pregnancy, breastfeeding and <12yrs
tetracycline. Advise to start the next pack of pills without a break.
AVOID MINOCYCLINE – can cause liver damage
• Lymecycline – lower risk of
but 2.5x more expensive than doxycycline
Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance MRSA ERADICATION
• Use all antibiotics cautiously in patients with a history of MRSA infection or colonisation as they are at high risk of recurrence. If systemic antibiotic therapy is required then use antibiotics which cover MRSA – seeks specialist advice.
• Not all isolates of MRSA indicate that there is an infection. Colonisation with MRSA is not an indication to use antibiotics. • For further information contact the Community Infection Control Team on 01287 284400 (south of Tees) or 01642 624203 (north
Not all patients wil require eradication treatment. Refer to
When eradication is needed:
• Mupirocin nasal ointment 2%, apply to both
For patients undergoing eradication encourage daily change
of flannel, towel and personal clothing and, if possible,
• Octenisan body wash once daily. (If excessive
Rescreen 2 days after completion of eradication
skin drying occurs consider Oilatum Plus as an
treatment. A patient cannot be regarded as MRSA-negative
until they have had three negative swabs taken at weekly intervals fol owing eradication treatment. Such patients may
still carry MRSA and MRSA should still be considered as the
• Hair wash with Octenisan twice in five-day
potential cause of any subsequent infections.
GASTRO-INTESTINAL TRACT INFECTIONS Detection and
• Testing for H.pylori should not be
First Line – Triple Therapy: Eradication of H. pylori
• One week triple treatment eradicates
Treatment Failure – Triple Therapy
• No need to continue PPI beyond If allergic to penicillin:
• Avoid clarithromycin or metronidazole
increases risk of C.difficile infection – consider if severe or prolonged diarrhoea fol owing treatment.
Gastroenteritis
Treatment should be considered on advice of microbiologist in severe
or invasive infections (severe systemic upset and/or dysentery).
Antibiotic therapy not usually indicated.
• Do not use anti-motility drugs if stools
Salmonella
Seek advice from microbiology / infectious diseases
infection (suspected)
prosthesis, bone metastases, haemoglobinopathy, chronic IBD
Shigella
Seek advice from microbiology / infectious diseases
infection (confirmed) Campylobacter
• Frequently self-limiting – treat if
infection (confirmed) Traveller’s
• Consider private prescription (ciprofloxacin 500mg twice daily x 3 days) to be carried by people travelling to
diarrhoea
remote areas or in whom an episode of diarrhoea could be dangerous – to be taken if il ness develops
• Empirical antibiotic treatment is unnecessary in most people. Seek advice from microbiology / infectious
Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance GASTRO-INTESTINAL TRACT INFECTIONS - continued Clostridium First-line: difficile
• Metronidazole 400mg three times daily
• Do not prescribe anti-motility drugs
Relapse:
• Repeat Metronidazole 400mg three times daily
Seek Microbiology advice if patient Severe / Relapse (usually in hospital): not responding to treatment
• Oral Vancomycin 125mg four times daily
• Admit to hospital if severe: temp.
>38C, WCC >15, rising creatinine or signs/symptoms of severe colitis
Threadworms Adult and Child > 6 months:
(A second dose may be needed after 2 weeks)
Child 3 months – 6 months:
• Piperazine oral powder one level 2.5ml spoonful
of dry powder mixed with milk or water to be
PROPHYLAXIS IN ASPLENIA / SPLENIC DYSFUNCTION Refer to BCSH
• Ensure patient is fully vaccinated –
Prevention of pneumococcal infection: Guidelines for full information about the Adult & child over 12 years: 500mg twice daily
management of Child 6 - 12 years: 250mg twice daily
asplenia Child 1 month – 6 years: 125mg twice daily
patients If allergic to penicillin: Adult & child over 12 years: 250-500mg daily
Child 2 – 12 years: 250mg daily
unwel . Patients developing infection must be given systemic antibiotics
Child 1 month – 2 years: 125mg daily
potential risks of overseas travel, particularly with regards malaria and unusual infections, e.g. those resulting from animal bites.
reliable – benefits are greatest in under-18s
Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance QUICK REFERENCE GUIDE TO THE MOST COMMON INFECTIONS Otitis media
• Many are viral. 80% resolve over 4 When antibiotics are needed: days without antibiotics. Consider First line:
• Amoxicillin <2 yrs: 125mg three times daily
• Unilateral pain in children >1 yr should
If allergic to penicillin:
• Erythromycin <2 yrs: 125mg four times daily
• Antibiotics do not reduce pain in first 24 >8 yrs: 250-500mg four times daily
hours, subsequent attacks or deafness. 2nd line options – co-amoxiclav, azithromycin (if
• Use regular paracetamol or ibuprofen
• Antibiotics are not indicated for When antibiotics are needed: Bronchitis First line options:
• Amoxicillin 500mg three times daily, or
irrespective of whether or not antibiotics
• Doxycycline 200mg stat then 100mg daily
• Antibiotics only needed if: When antibiotics are needed: exacerbation First line options:
• Amoxicillin 500mg three times daily, or
• If antibiotics are needed and patient
• Doxycycline 200mg stat then 100mg daily
allergic to penicillin and clinical failure to doxycycline: use Second Line:
clarithromycin (see BNF) but reserve for
• Doxycycline 200mg stat then 100mg daily
• Co-amoxiclav 625mg three times daily
First line options: Uncomplicated
morning urine increase likelihood of UTI
UTI in women
Avoid nitrofurantoin in CKD stage 3/4/5,
• Nitrofurantoin 50-100mg four times daily
2nd line treatments according to C&S
Impetigo
• Patients are infectious until lesions have
First line:
• Flucloxacillin 500mg four times daily
If allergic to penicillin:
Reserve topical antibiotics (fusidic acid)
Adults & children able to take tablets:
only – have a low threshold for systemic treatment
Children & adults requiring liquid formulation:
• Reserve mupirocin for nasal eradication
Cellulitis
• If patient afebrile and healthy other First line: than cellulitis, flucloxacillin may be
• Flucloxacillin 500mg four times daily
used as single drug treatment.
• If febrile, il or rapidly worsening infection
• Phenoxymethylpenicllin 500mg four times daily
If allergic to penicillin:
• In facial cellulitis use co-amoxiclav
completely resolved after the initial 7 day 2nd line (poor response to above after 48 hours): If facial involvement:
• Co-amoxiclav 500/125mg three times daily
consider referral to specialist service.
If caused by trauma or wound exposed to water –seek specialist advice Bacterial
• Treat pregnant women with First line: Vaginosis asymptomatic bacterial vaginosis. If compliance likely to be a problem:
for women with history of preterm birth or
• Metronidazole 2g single dose (not if pregnant)
If patient pregnant:
• Advise cautious insertion of applicator in
• Clindamycin 2% cream insert one 5g applicator
• If woman not pregnant, only treat if
If breast feeding:
• Metronidazole 0.75% gel insert one 5g
• Oral metronidazole tablets give breast
applicator full into the vagina at night
milk a bitter taste and may stop the baby feeding.
Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011. Community Infection Guidance Information Collated from: • Health Protection Agency Management of Infection Guidance for Primary Care, July 2010 • Clinical Knowledge Summaries, accessed January-September 2010, http://www.cks.nhs.uk
• South Tees Hospitals NHS Trust Antimicrobial drugs: a guide to the treatment of common infections,
• NICE Guidance – Management of dyspepsia in adults in primary care; August 2004
• NICE Clinical Guidelines, UTI in Children, August 2007
• NICE Clinical Guidelines, Respiratory Tract Infections, August 2008 • The National Teratology Information Service – Metronidazole in Pregnancy
• British Committee on Standards in Haematology, Guidance for the prevention and treatment of infection
in patients with an absent or dysfunctional spleen, 2002
• DECENT Guidelines – Antibiotic treatment of foot complications in people with diabetes, 2010
• Newcastle Childhood UTI Guidelines, 2008 We are grateful to Consultants and the Antibiotic Working Groups at South Tees Hospitals Foundation Trust and North Tees & Hartlepool Foundation Trust, and to everyone else who has contributed to this guidance.
Developed by: Dr.Jonathan Berry, GP, Stockton-on-Tees Joanne Madden, Prescribing Adviser, NHS Hartlepool / NHS Stockton-on-Tees Richard Morris, Prescribing Adviser, NHS Middlesbrough / NHS Redcar & Cleveland Dr.Janet Walker, GP, Redcar & Cleveland Note: Doses are oral and for adults unless otherwise stated. Please refer to BNF/BNF-C/SPC for further information. Guidance updated September 2010. Next review due September 2011.
HITCH – DER DATE-DOKTOR HITCH Regie: Andy Tennant Darsteller Länge 113 Cinemascope Stabliste HITCH – DER DATE-DOKTOR „Egal wie, egal wann, egal wer: Jeder Mann hat die Chance, eine Frau vonden Füßen zu fegen – vorausgesetzt, er hat den richtigen Besen.“ So lauteteine der Weisheiten von Alex „Hitch“ Hitchens, und der muss es wissen,denn Hitch, genannt der �
Too much caffeine during pregnancy may increase the risk ofmiscarriage, a new study says, and the authors suggest that pregnantwomen may want to reduce their intake or cut it out entirely. Many obstetricians already advise women to limit caffeine, though the subject has long been contentious, with conflicting studies, fuzzy data and various recommendations given over the years. The new stud