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MATERIAL SAFETY DATA SHEET
GENESIS® (triamcinolone acetonide)Topical Spray
Product Codes: 410500 and 410508
IDENTIFICATION OF THE SUBSTANCE/PREPARATIONS AND OF THE COMPANY UNDERTAKING
Product Name
Product Description
Manufacturer/Supplier
Phone Number
Chemtrec Number (24 hour)
Emergency Number:
(800) 338-3659 for Human and Animal Medical Emergencies MSDS Revision Date:
Supersedes MSDS Dated:
Material Safety Data Sheet in compliance with OSHA’s Hazcom Standard (29 CFR 1910.1200) HAZARDS IDENTIFICATION
Emergency Overview
CAUTION!

Routes of Entry
Eye contact - Skin contact - Ingestion - Inhalation
Carcinogenic Status
Not considered carcinogenic by NTP, IARC, and OSHA.
Target Organs
Eyes - Skin - Respiratory System - Central Nervous System - Kidneys - Liver - Heart
Health Effects - Eyes
Contact with eyes can cause irritation.
Health Effects - Skin
Contact with skin may cause slight irritation.
Health Effects - Ingestion
Harmful if swallowed. Ingestion of this material may cause gastrointestinal effects such as nausea,
vomiting and diarrhea. Repeated ingestion may cause adverse effects to liver, kidney and heart and
central nervous system depression.
Health Effects - Inhalation
Prolonged, repeated inhalation of spray, mist or vapors may cause respiratory irritation and other
adverse health effects.
COMPOSITION/INFORMATION ON INGREDIENTS
Component Name
CAS Number
Concentration
Revision Date: March 2, 2011
Page 1 of 6
Material Safety Data Sheet
GENESIS® (triamcinolone acetonide)Topical Spray
Product Codes: 410500 and 410508
COMPOSITION/INFORMATION ON INGREDIENTS
Component Name
CAS Number
Concentration
FIRST AID MEASURES
Eyes
Immediately flood the eye with plenty of water for at least 15-20 minutes, holding the eye open. Obtain
medical attention if soreness or redness persists.
Skin
If irritation develops wash skin thoroughly with soap and water. Obtain medical attention if redness or
soreness persists.
Ingestion
Call a poison control center or doctor immediately for treatment advice. Do not induce vomiting unless
told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious
person.
Inhalation
Remove person to fresh air. Seek medical attention if symptoms persist.
Advice to Physicians
Treat symptomatically.
FIRE - FIGHTING MEASURES
Extinguishing Media
Use extinguishing media appropriate for surrounding materials.
Unusual Fire and Explosion Hazards
Can release hazardous vapors during a fire.
Protective Equipment for Fire-Fighting
Wear full protective clothing and self-contained breathing apparatus.
ACCIDENTAL RELEASE MEASURES
Wear appropriate protective clothing. Wipe up and transfer into suitable containers for recovery or disposal. Prevent the material from entering drains or watercourses. HANDLING AND STORAGE
Store in original container in a cool, dry place. Store away from children and pets. Do not store near foodstuffs. Do not contaminate water, food or feed by storage. Wear gloves and other appropriate protective clothing. Avoid contact with eyes and skin. Wash hands thoroughly after handling and before eating, drinking or smoking. Store at room temperature between 59oand 86oF. EXPOSURE CONTROLS/PERSONAL PROTECTION
Occupational Exposure Standards
Exposure limits are listed below, if they exist.
Ethyl Alcohol
ACGIH: 1000 ppm 15-min STEL
OSHA: PEL 1000ppm (1900 mg/m3) 8h TWA
Revision Date: March 2, 2011
Page 2 of 6
Material Safety Data Sheet
GENESIS® (triamcinolone acetonide)Topical Spray
Product Codes: 410500 and 410508
EXPOSURE CONTROLS/PERSONAL PROTECTION
Propylene Glycol
None established
Triamcinolone Acetonide
None established
DMDM Hydantoin
None established
Engineering Control Measures
No specific measures necessary. Good general room ventilation is expected to be adequate to control
airborne levels.
Respiratory Protection
Not required under normal conditions of use. Professional groomers and those with repeated and
extended exposures should consider the use of respiratory protection if there is a risk of exposure to
high vapor concentrations or aerosols. The specific respirator selected must be based on the airborne
concentration found in the workplace and must not exceed the working limits of the respirator.
Hand Protection
Chemical resistant gloves.
Eye Protection
Safety glasses or goggles.
Body Protection
Waterproof apron.
PHYSICAL AND CHEMICAL PROPERTIES
Physical State
Specific Gravity
Boiling Range/Point (°C/F)
Melting Point (°C/F)
Flash Point (PMCC) (°C/F)
Explosion Limits (%)
Vapor Pressure
Solubility in Water
Vapor Density (Air = 1)
STABILITY AND REACTIVITY
Stability
Stable under normal conditions.
Conditions to Avoid
Heat - high temperatures
Materials to Avoid
Strong oxidizers – strong acids - bases
Hazardous Polymerization
Will not occur.
Hazardous Decomposition Products
Oxides of carbon – organic compounds
Revision Date: March 2, 2011
Page 3 of 6
Material Safety Data Sheet
GENESIS® (triamcinolone acetonide)Topical Spray
Product Codes: 410500 and 410508
TOXICOLOGICAL INFORMATION
See product insert and packaging for additional information.
Acute Toxicity
Propylene Glycol: Oral LD50 (rat) 22,000 mg/kg
Ethyl Alcohol: Oral LD50 (rat) 7060 mg/kg
Triamcinolone Acetonide: Oral LD50 (Rat) 5000 mg/kg Dermal LD50 (rabbit ) >402mg/kg
DMDM Hydantoin: Oral LD50 (rats) 2000-5000 mg/kg
Specific Target Organ Systemic Toxicity (single and repeat)
Propylene Glycol: In animal studies propylene glycol has been shown to cause kidney damage.
Ethyl Alcohol: Chronic exposure can result in adverse liver, heart and central nervous system effects.
Triamcinolone Acetonide: May cause adverse effects to the endocrine system (Cushing’s syndrome).
Triamcinolone acetonide is a highly potent synthetic glucocorticoid, which is primarily effective because
of its anti-inflammatory activity. Topical corticosteroids can be absorbed from normal intact skin.
Studies have demonstrated that topical preparations of triamcinolone have decreased plasma cortisol
levels and suppressed the response to ACTH.
Serious Eye damage/Eye Irritation
Propylene Glycol: Mild eye irritation (rabbit)
Ethyl alcohol: Causes severe eye irritation.
Triamcinolone Acetonide: Eye irritation – mild (rabbit)
Skin Corrosion/Irritation
Propylene Glycol: Mild skin irritation (human, 7d)
Triamcinolone Acetonide: Skin irritation – negative (rabbit)
DMDM Hydantoin: Caused minimal transient irritation in laboratory studies on albino rabbits.
Respiratory or Skin Sensitization
No relevant studies identified.
Carcinogenicity
Not considered carcinogenic by NTP, IARC, and OSHA.
Germ Cell Mutagenicity
Triamcinolone Acetonide: Laboratory experiments have shown mutagenic effects.
DMDM Hydantoin: Both positive and negative mutagenicity results in laboratory studies.
Toxicity to Reproduction
Ethyl Alcohol: Ingestion of ethyl alcohol during pregnancy has caused adverse reproductive effects
(fetal alcohol syndrome) but only at doses that are maternally toxic.
Triamcinolone Acetonide: May cause congenital malformation in the fetus. Presumed human
reproductive toxicant.
ECOLOGICAL INFORMATION
Mobility
No relevant studies identified.
Persistence/Degradability
No relevant studies identified.
Bio-accumulation
No relevant studies identified.
Ecotoxicity
Propylene Glycol: EC50 Daphnia magna > 10,000 mg/l 48 h
DISPOSAL CONSIDERATIONS
Dispose of in accordance with all applicable local and national regulations. Revision Date: March 2, 2011
Page 4 of 6
Material Safety Data Sheet
GENESIS® (triamcinolone acetonide)Topical Spray
Product Codes: 410500 and 410508
TRANSPORT INFORMATION
DOT CFR 172.101 Data
UN Proper Shipping Name
UN Number
UN Packaging Group
Classification for AIR
Consult current IATA Regulations prior to shipping by air. Transportation (IATA)
REGULATORY INFORMATION
US REGULATIONS (Federal, State) and INTERNATIONAL CHEMICAL REGISTRATION LAWS
TSCA Listing
This product contains ingredients that are listed on or exempt from listing on the EPA Toxic Substance
Control Act Chemical Substance (TSCA) Inventory.
DSL (Canadian) Listing
This product contains ingredients that are listed on the Domestic Substance List (DSL) or Non-
Domestic Substance List (NDSL).
WHMIS Classification
D.2.B
This product was classified in accordance with the hazard criteria of the Canadian Controlled Products Regulations and the MSDS contains all the information required by these regulations. MA Right To Know Law
This product contains the following chemicals on the Massachusetts Right to Know Law: Ethyl Alcohol
(64-17-5)
PA Right To Know Law
This product contains the following chemicals on the Pennsylvania Hazardous Substance List:
Propylene Glycol (57-55-6) - Ethyl Alcohol (64-17-5) - Formaldehyde (50-00-0) <0.02%
NJ Right To Know Law
This product contains the following chemicals on the New Jersey Workplace Hazardous Substance
List: Ethyl Alcohol (64-17-5)
California Proposition 65
This product contains the following materials which the State of California has found to cause cancer,
birth defects or other reproductive harm: Formaldehyde (50-00-0) <0.02%
SARA Title III Sect. 311/312 Categorization
Immediate (acute) Delayed (chronic)
SARA Title III Sect. 313
This product contains the following chemicals that are listed in Section 313 at or above de minimis
concentrations: None
OTHER INFORMATION
NFPA Ratings
NFPA Code for Flammability - 0
NFPA Code for Health - 1
NFPA Code for Reactivity - 0
NFPA Code for Special Hazards – 0
Revision Date: March 2, 2011
Page 5 of 6
Material Safety Data Sheet
GENESIS® (triamcinolone acetonide)Topical Spray
Product Codes: 410500 and 410508
OTHER INFORMATION
HMIS Ratings
HMIS Code for Flammability - 0
HMIS Code for Health – 1*
HMIS Code for Reactivity - 0
HMIS Code for Personal Protection - See Section 8
Abbreviations
ACGIH: American Conference of Governmental Industrial Hygienists
BOD: Biological Oxygen Demand
CAS#: Chemical Abstracts Service Number
FIFRA: Federal Insecticide, Fungicide and Rodenticide Act
IARC: International Agency for Research on Cancer
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
N/A: Denotes no applicable information found or available
NTP: National Toxicology Program
OSHA: Occupational Safety and Health Administration
PEL: Permissible Exposure Limit
STEL: Short Term Exposure Limit
TLV: Threshold Limit Value
TSCA: Toxic Substance Control Act
For further Information call:
Prepared By:
GENESIS is a registered trademark of Virbac AH, Inc. The information and recommendations presented in this MSDS are based on sources believed to be
accurate. Virbac AH, Inc. assumes no liability for the accuracy or completeness of this information. It is
the user's responsibility to determine the suitability of the material for their particular purposes. In
particular, we make NO WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY,
EXPRESS OR IMPLIED, with respect to such information, and we assume no liability resulting from its
use. Users should ensure that any use or disposal of the material is in accordance with applicable
Federal, State, and local laws and regulations.
Revision Date: March 2, 2011
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Source: http://www.virbacvet.com/pdf/product_pdfs/GENESIS_Topical_Spray_msds.pdf