Microsoft word - sample mcq questions.doc

Sample MCQ Questions

PHARMACEUTICAL CHEMISTRY
1 Which is NOT true for the substance with the following chemical structure?
2 The compound with the following structure is (_)-3-(3,4-dihydroxyphenyl)-L- alanine. Select the most appropriate statement below. 3 Ibuprofen has a pKa of 5.5. If the pH of the patient's urine is 7.5. What is the ratio of dissociated to undissociated drug? 4 Sulfonamides are metabolised by humans principally by 5 In which drug is the pharmacological activity associated with a specific optical 6 The functional group which contributes to the instability of aspirin is Which of the following therapeutic classifications does the chemical structure above 9 Which of the following drugs would NOT be expected to show appreciable
absorbance in the ultraviolet region of the electromagnetic spectrum? 10 The ultraviolet region of the spectrum used in drug analysis *C contain a centre or plane of asymmetry 12 Which of the following drugs is LEAST likely to cause electrolyte
13 Which one of the following elements is radioactive? 14 The structure pictured below is characteristic of 15 Which of the following co-factors are required for drug metabolising enzymes? *A reduced nicotinamide-adenine dinucleotide phosphate (NADPH) and oxygen B reduced nicotinamide-adenine dinucleotide (NADH) and oxygen In the scheme above, the structural formula for quinidine is PHARMACOLOGY and PHYSIOLOGY
18 The long term administration of a thiazide diuretic may also require the 19 Which one of the following symptoms is associated with A is used for treatment of allergic rhinitis B inhibits the release of histamine from mast cells D prevents bronchoconstriction due to histamine E may be used for the treatment of asthma 21 Cyproheptadine can best be classified pharmacologically as an 22 Which of the following drugs has an anti-inflammatory action? 23 Which of the following statements regarding the stimulation of peripheral 24 The antimicrobial action of the cephalosporins can best be explained on the A competitive antagonism of purine precursors B stimulation of nucleic acid production 25 Which of the following is not a white blood cell? 26 The compound with the following structure is a hormone By which of the following is this hormone secreted? 27 The major determinant of myocardial oxygen consumption is 28 Which of the following is a pharmacological action of histamine? 29 Which of the following antibiotics is NOT readily destroyed by penicillinase
D used in the treatment of cardiac arrhythmias *E a combined α/β adrenergic receptor blocker 31 Streptokinase may be indicated for the treatment of 32 Exophthalmic goitre is associated with *A diffuse hyperplasia of the thyroid gland E decreased responses to mental and emotional stimuli 33 Which of the following statements applies to the use of 8.4% sodium bicarbonate solution, given intravenously, as a treatment for cardiac arrest? [Atomic weights - Na A the solution has a pH very close to the pH of blood *B the solution provides 1000 millimoles per litre of sodium ion C the bicarbonate ion has a stimulating effect on the heart D in an emergency, a similar effect can be obtained by breathing PHARMACEUTICS
34 An ingredient that is added to a tablet formula to improve flow properties into a 35 Which of the following when dispensed should carry the cautionary label: 36 Which of the following is the first process that must occur before a drug can become available for absorption from a tablet dosage form? *A dissolution of the drug in the GI fluids B dissolution of the drug in the epithelium 37 Which route of administration would provide the most rapid onset of A the time to reach a plateau concentration depends upon the rate of infusion *B all drugs having the same clearance reach the same plateau concentration C drugs with the same clearance generally reach the plateau concentration at the D the amount of drug in the body at the plateau cannot be the same when drugs with different clearance values are infused at the same rate E the time to go from one plateau concentration to another depends upon both the half-life of the drug and the new infusion rate 39 An antibiotic which has a half-life of one day is formulated as a 200 mg tablet. How many milligrams of antibiotic would remain after three days? 40 Which one of the following drugs exhibits nonlinear pharmacokinetics at normal 41 Sodium chloride equivalents are used to estimate the amount of sodium chloride needed to render a solution isotonic. The sodium chloride equivalent or "E" value *A amount of sodium chloride that is theoretically equivalent to one gram of a B amount of a specified chemical theoretically equivalent to one gram of sodium C milliequivalents of sodium chloride needed to render a solution isotonic D weight of a specified chemical that will render a solution isotonic E percent sodium chloride needed to make a solution isotonic 42 For many drugs, bioavailability can be evaluated using urinary excretion data. A bioavailability studies can be done only on drugs that are completely excreted B drug levels can be measured more accurately in urine than in blood *C a drug must be first absorbed into the systemic circulation before it can appear in D all of the administered dose can be recovered from the urine E only drug metabolites are excreted in the urine 43 The renal excretion of a weakly acidic drug of pKa 3.5 will be more rapid in alkaline urine than in acidic urine because A all drugs are excreted more rapidly in alkaline urine B the drug will exist primarily in the unionised form, which cannot easily be *C the drug will exist primarily in the ionised form, which cannot be easily D weak acids cannot be reabsorbed from the kidney tubules E active transport mechanisms function better in alkaline urine 44 If a fixed dose of a drug that is eliminated by first-order kinetics is administered at regular intervals, the time required to achieve a steady-state plasma level depends E fraction of dose absorbed (bioavailability) 45 Active immunity can be conferred by the administration of 46 The presence of Pseudomonas aeruginosa would be of particular danger in an 47 The correct method of parenteral administration of potassium chloride is by 48 The antibacterial activity of phenols is increased by C the presence of 10% vegetable oil phase D the presence of 1% polysorbate 20 (tween 20) E the addition of a quaternary ammonium compound THERAPEUTICS
49 Patients prescribed irreversible monoamine oxidase inhibitors should be warned not to consume foods containing tyramine because the combination may cause *B acute adrenergic crisis including severe hypertension 50 Early symptoms of aspirin poisoning are *E ringing in the ears and blurred vision 51 When central nervous system depressants are prescribed which of the following should NOT be ingested at the same time?
52 Which of the following drugs would be most likely to produce intestinal perforation if used in the treatment of a patient with ulcerative colitis and diarrhoea? Make an isotonic solution Prepare 25 mL. (NaCl equivalent of amethocaine hydrochloride = 0.19) How many grams of anhydrous dextrose are needed to prepare an isotonic solution of amethocaine in the above prescription? 54 A 5 mg dose of nitrazepam administered to an adult will act as 55 A pharmacist has 50mL of 0.5% chlorhexidine solution. What will be the final ratio strength if the pharmacist dilutes this solution to 1250mL with purified water? 56 The concentration of benzalkonium chloride used as a preservative in eye 57 The usual adult daily dose of phenytoin is in the range of 58 How many millimoles of potassium are there in 500mg of potassium chloride? 59 You are requested to prepare an admixture of isoprenaline hydrochloride 2mg, in 500 mL of 5% Dextrose Injection. Available are 5 mL ampoules of Isoprenaline Hydrochloride Injection 1 in 5000. How much of the additive is to be added? Potassium 10 mMoles Orange syrup to make 5 mL Take 5 mL four times a day and sufficient for three days How many grams of potassium gluconate C6H11O7K, molecular weight = 234, 61 What is a major contraindication to the use of over-the-counter medications 62 Glucose-6-phosphate dehydrogenase (G6PDH) deficiency is an inherited error of metabolism estimated to occur in over 100 million persons. The enzyme is needed to reduce oxidized glutathione, and in deficient persons, red blood cells are susceptible to haemolysis in the presence of oxidising agents, including certain drugs. The antimalarial drug to avoid in G6PDH deficiency is 63 What advice would you give to a patient prescribed rifampicin tablets? A take this medication with food or milk B avoid multi-vitamin preparations while undergoing treatment with this medication C avoid taking paracetamol while undergoing treatment with this medication D possible discolouration of the skin is of no importance *E this medication may cause discolouration of the urine

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