Microsoft word - roadmap for pediatric dermatology at the sid-1.docx
Roadmap for Pediatric Dermatology at the SID **Clinical Scholars program and Young Investigator and Trainee symposium are only open to those who sign up in advance (free). If you have not, we encourage you to sign up while there are still spaces. Anyone interested in meeting Weds. evening at the Welcome Reception: Gather 7:30-8:00 pm at the statue of Sir Walter Raleigh on the patio (unless raining; if raining, by the base of the staircase in the lobby of the convention center). Raleigh Convention Center Grand Lobby and Outside Patio WEDNESDAY, May 9, 2012 International Pachyonychia Congenita Consortium (PC Project) 9:00 am - 3:00 pm Raleigh Convention Center 301 A/B 8:00 am – 3:00 pm (Pre-meeting Breakfast — 7:00 am – 7:45 am) Morning Jakub Tolar: Harnessing Stem Cell Gene Biology to Combat Genodermatoses Section 1: Diagnostics and Genetics (Dennis Roop) New approaches to the diagnostics of genodermatoses: Gabriele Richard Update on Pachyonychia Congenita Genetics: Frances J.D. Smith Frizzled 6 Gene: Regina C. Betz Section 2: Research Studies (E. Birgit Lane) Review of the GO Delivery! Grant: Christopher H. Contag Keratinocytes and Pain: Michael J. Caterina Nucleoside-modified messenger RNA for gene therapy: Katalin Kariko and Drew Weissman Update on Pachyonychia Congenita Research at TransDerm: Roger L. Kaspar et al. K16 Null Mice: Juliane C. Kellner, Pierre A. Coulombe Keratins, Pachyonychia Congenita and Research Advances: W. H. Irwin McLean Afternoon Section 3: PC Physician Network (Maurice van Steensel) Trials and Tribulations: John A. McGrath Towards Differential Diagnosis: What We Have Learned From The IPCRR: Edel A. O’Toole Developing Best Practices For Pachyonychia Congenita: Ilan Goldberg Painless Biopsies for PC Plantar Keratoderma: Leonard M. Milstone DISCUSSION: Moving forward with clinical studies for Pachyonychia Congenita: Eli Sprecher American Acne and Rosacea Society 10:30 am - 12:00 pm Raleigh Convention Center 302 A Overview: Diane Thiboutot Recent Advances in Acne and Rosacea Research: Jenny Kim 1. Mast cells and neuropeptide expression are increased in erythematotelangiectatic rosacea in comparison to telangiectatic photoaging. Yolanda Helfrich et al. 11:00 am, Poster #093 2. Inhibition of Rho-associated protein kinase (ROCK) allows for indefinite expansion of cultured human sebocytes. Melanie Dispenza et al. 11:10 am, Poster #454
3. Developing a novel personalized interactive health care education system (MyPACE) for acne patients. Audrey S Wang et al. 11:20 am, Poster #511 4. IL-17A is involved in P. acnes-induced inflammation. George W Agak et al. 11:30 am, Poster #633 5. Oxidized fatty acids and inflammatory response in acne: A potential therapeutic role for apolipoprotein A-I (apoA-I) mimetic peptide 4F as an anti-inflammatory agent. Aslan Pirouz, et al. 11:40 am, Poster #085 Atopic Dermatitis Conference 12:00 pm - 3:00 pm Raleigh Convention Center Ballroom B/C Introduction and Welcome: Lisa Beck No Place Like HOME: Goals of HOME and its Progress to Date and Plans for the Future: Hywel Williams Solid Gold? Should IGA Be the “Gold Standard” for AD Assessment?: Eric Simpson Coming to Our Senses: Assessment Tools for Itch: Gil Yosipovitch Hitting the Mark—AD Biomarkers: How good are they?: Emma Guttman-Yassky Hurdles in the Development of AD Therapeutics: Neil Graham Casting a Wide Net: Genetic & Epidemiological Insights: David J. Margolis Irvin H. Blank Forum 3:00 pm - 5:00 pm Translating the Genetics of Disease into Therapeutics Raleigh Convention Center Ballroom B/C Introduction: Todd Ridky Rare and Common Variants in Medical Genetics: David V. Goldstein Mutations in CARD14 Lead to Psoriasis: Eli Robertson Exploring the Therapeutic Potential of Induced Pluripotent Stem (iPS) Cells for Inherited Skin Blistering Diseases: Dennis Roop Albert M. Kligman/Phillip Frost Leadership Lecture 5:00 pm - 5:30 pm Keeping an Eye on Cutaneous Biology Robert Lavker Raleigh Convention Center Ballroom B/C State-of-the-Art Plenary Lecture 1 5:30 pm - 6:00 pm Stem Cell Regulation by Stem Cells in Hair Follicles Emi Nishimura Raleigh Convention Center Ballroom B/C State-of-the-Art Plenary Lecture 2 6:00 pm - 6:30 pm Opportunities for Discovery Utilizing Next Generation Sequencing Technology Keith Choate Raleigh Convention Center Ballroom B/C Welcome Reception 7:00 pm - 8:30 pm Raleigh Convention Center Grand Lobby and Outside Patio
Note: All interested in pediatric dermatology can gather from 7:30-8:00 pm at the statue of Sir Walter Raleigh on the patio (unless raining; if raining, by the base of the staircase in the lobby of the convention center). THURSDAY, May 10, 2012 Pediatric Dermatology Morning Session, 7:00 - 8:00 am [Coffee served] Raleigh Convention Center 206 Overview I: Pediatric Dermatology at SID: Amy Paller 1. Functional analysis of candidate genes identified by genomewide association study (GWAS) of infantile hemangiomas (IH). Mary Kwon et al. 7:15 am, Poster #393 2. Therapies for dystrophic epidermolysis bullosa require close evaluation for development of antibodies to type VII collagen. Emily S Gorell, et al. (Presented by Al Lane) 7:25 am, Poster #399 3. Eczema severity is associated with multiple comorbid conditions and increased healthcare utilization. Jonathan Silverberg and Eric L Simpson. 7:35 am, Poster #260 Plenary Session I 8:00 am - 9:00 am Raleigh Convention Center Ballroom B/C 1. Epigenetic regulation of cathelicidin expression by PTH/PTHrP controls skin infection. Beda Muehleisen et al. 8:00 am, Poster #638 2. GLI2* engages the mTOR pathway to drive development of malignant peripheral nerve sheath tumors (MPNSTs) in skin. Alexandre N Ermilov et al. 8:12 am, Poster #177 3. Efforts to provide a comprehensive overview of genetic changes in canine melanoma as a means to identify genetic correlates for drug response. Aleksandar Sekulic et al. 8:24 am, Poster 781 4. Germline mutation in ATR underlying a new autosomal dominant oropharyngeal cancer syndrome. Akio Tanaka, et al. 8:36 am, Poster #404 5. PDK1 regulates keratinocyte differentiation. Teruki Dainichi, et al. 8:48 am, Poster #298
Eugene M. Farber Lecture 9:00 am - 9:30 am Genomics Meets the Immune System: An Integrated Systems Perspective on Psoriasis Frank Nestle Raleigh Convention Center Ballroom B/C Naomi M. Kanof Lecture 9:30 am - 10:00 am The Neurofibroma Story: A Role for Mast Cells in Tumor Potentiation and Clinical Implications Luis Parada Raleigh Convention Center Ballroom B/C Poster Session I/Technical Exhibits Open w/coffee break 10:00 am - 12:00 pm Odd 001-287 / Even 288-574 Raleigh Convention Center Exhibit Hall A Special: Poster session on Pediatric Dermatology led by Raegan Hunt 10:25-10:55 Meet by 10:25 inside the poster session to the left of the doorway Research in Cutaneous Surgery symposium Raleigh Convention Center 305 A 10:50: Dermal matrix composition promotes development of aggressive squamous cell carcinoma in recessive dystrophic epidermolysis bullosa. Yi-Zhen Ng et al. Poster #119 **Young Investigator and Trainee Symposium 10:00 am - 1:30 pm Developing an Academic Career Raleigh Convention Center 302 A Moderator: Kristina Callis Duffin What Does an Academic Career in Investigative Dermatology Really Mean, and is it Right for You? Amy Paller Finding the Right Job and Negotiating a Contract. John Zone Making the Most of Mentorship: From Finding a Mentor to Being One. Angela Christiano Funding: A Brief Overview of Funding Opportunities Available to Young Investigators, and Strategies to Improve Your Grant Application. Kim Yancey Putting It All Together: Words of Advice on Finding a Niche, Building Collaborations, and Mentoring. Joel Gelfand What Can the SID Do for Me? Jodi Johnson **Clinical Scholars Plenary Session 10:15 am - 12:15 pm Raleigh Convention Center 305 B 1. Skin commensal bacteria acts as antimicrobial shield: Identification of firmocidin, a novel small molecule antibiotic produced by Staphylococcus epidermidis: Richard Gallo 10:20 am, Poster #642 2. Response to self antigen imprints regulatory memory in the skin: Michael Rosenblum 10:40 am, Poster #107 The mTOR Pathway and Dermatologic Disease: Tom Darling Stem Cell Therapy/Epidermolysis Bullosa: Katsuto Tamai Concurrent Minisymposia 2:00 pm - 5:30 pm
Auto-immunity and Inflammation Raleigh Convention Center 306 C Ceramide deficiency in the epidermis leads to development of psoriasis-like lesions associated with IL-23-dependent proliferation of γδ-17 cells. Kimiko Nakajima 2:00 pm, Poster #103 IL-15 is a therapeutic target in human alopecia areata. Luzhou Xing. 2:36 pm, Poster #104 Effective prevention and treatment of CD8 T cell-mediated Graft-versus-host-like disease (GvHD) using a JAK inhibitor. Naoko Okiyama. 2:48 pm, Poster #040 Host genetics play a role in controlling skin bacterial species and autoimmune blistering skin disease. Girish Srinivas. 3:00 pm, Poster #039 Response to self antigen imprints regulatory memory in the skin. Michael Rosenblum. 3:24 pm, Poster #107
CD103-positive CD4+Foxp3+ T regulatory cells are necessary for optimal suppression of cutaneous inflammation. Jane Yoo. 3:36 pm, Poster #087 Inhibition of the SDF-1/CXCR4 axis alleviates chronic and acute skin inflammation. Silvana Zgraggen. 3:48 pm, Poster #008 Identification of cytotoxic T cell epitopes in alopecia areata. Eddy Wang. 4:00 pm, Poster #015 IL-17 Receptor A subunit is a central hub for inflammatory signaling in human psoriasis. Chris B Russell. 4:12 pm, Poster #041 Scurfy mice reveal strong autoimmune skin inflammation with Th2-deviation of skin-infiltrating CD4+ T cells and high epidermal expression of thymic stromal lymphopoietin (TSLP). Eva N Hadaschik. 4:24 pm, Poster #046 Anti-desmoglein 1 autoantibodies from Fogo Selvagem recognize LJM11, a member of the “yellow” family of salivary proteins from Lutzomyia longipalpis. Ye Qian. 4:36 pm, Poster #054 Identification of cytotoxic T cell epitopes in alopecia areata. Eddy Wang. 4:48 pm, Poster #077 Cell Adhesion/Matrix Biology Raleigh Convention Center 302 B Distinct functions of α6β4 and α3β1 integrins in keratinocyte migration. Kristina R Kligys. 2:48 pm, Poster #202 Uncovering functional differences between kindlin-1 and kindlin-2 in keratinocytes. Aditi Bandyopadhyay. 3:36 pm, Poster #219 Development of a vascularized skin equivalent with a physiological perfused vascular network. Florian K Groeber. 4:24 pm, Poster #199 Epidemiology/Health Services Research Raleigh Convention Center 306 B Comparative effectiveness of commonly used systemic treatments or phototherapy for moderate to severe plaque psoriasis in clinical practice. J M Gelfand. 2:48 pm, Poster #228 Filaggrin mutations: Prognosis and response to therapy overtime. David J Margolis. 3:00 pm, Poster #243 Molecular epidemiology of non-syndromic ARCI in a Middle Eastern population. Shirli Israeli. 3:12 pm, Poster #250 Relative humidity, dew point, indoor heating and ultraviolet index are associated with the prevalence of eczema. Jonathan I Silverberg. 3:24 pm, Poster #261 Treatment satisfaction with commonly used treatments for moderate to severe plaque psoriasis in clinical practice. Howa Yeung. 4:12 pm, Poster #223 Factors related to the impact of pruritus on quality of life. Christopher Carr. 4:24 pm, Poster #230 Hair and Cutaneous Development Raleigh Convention Center 305 A Disruption of Tsc2 in dermal mesenchymal cells of mice results in skin defects observed in tuberous sclerosis complex. P Klover.2:00 pm, Poster #456 Conditional knock-in expression of a CYLD mutant leads to the abnormal growth of sebaceous glands. Jane Jin. 2:12 pm, Poster #442 A position effect on FGF13 underlies X-linked hypertrichosis. Gina M DeStefano. 2:24 pm, Poster #450
Plasticity and cellular memory during epidermal differentiation in response to BRAF activation and inhibition. Suguna R Krishnaswami. 2:36 pm, Poster #494 p63 transcription factor controls the establishment of nuclear architecture and higher-order chromatin remodelling during development of the epidermis. Michael Y Fessing. 2:48 pm, Poster #461 The polarity protein aPKCλ regulates epidermal cell fate decisions. Michaela Niessen. 3:00 pm, Poster #469 Wnt signaling in embryonic dermal papilla precursor cells is required for hair follicle morphogenesis. Su-Yi Tsai. 3:12 pm, Poster #453 Dermal β-catenin activity in response to epidermal Wnt ligands is required for hair follicle initiation. Demeng Chen. 3:24 pm, Poster #482 The regulation of dermal papilla cell number to specify hair size. Bruce A Morgan. 3:36 pm, Poster #484 Dkk family members pattern the development of multiple types of ectodermal appendage. Mingang Xu. Philadelphia, PA. 3:48 pm, Poster #452
FRIDAY, May 11, 2012
Pediatric Dermatology Session 7:00 am - 8:00 am [Coffee served] Raleigh Convention Center 206 Overview II: Pediatric Dermatology at SID Amy Paller, MD, Northwestern University Presentations Development of induced pluripotent stem cell-based therapy for pseudoxanthoma elasticum. Shunsuke Takahagi (Presented by Jouni Uitto). 7:15 am, Poster #832 Special Presentation: Progress in Understanding Alopecia Areata: Angela Christiano. 7:25 am
Plenary Session II 8:30 am - 9:30 am Raleigh Convention Center Ballroom B/C 1. Cardiovascular risk factors and risk for recurrent cardiovascular events among psoriasis patients undergoing cardiac catheterization. Jason M Farrow. 8:30 am, Poster #240 2. Neutralization of IL-17A with LY2439821 compared to TNF with etanercept: effects on inflammatory gene expression underlying psoriasis pathogenesis. James Krueger. 8:42 am, Poster #498 3. Overexpression of TGFβ1 in murine epidermis alters skin dendritic cell homeostasis and enhances adaptive immunity. Javed Mohammed. 8:54 am, Poster #609 4. Inhibition of wound-induced hair neogenesis by prostaglandin D2. Amanda M Nelson. 9:06 am, Poster #783 5. Toll-like receptor 2 signaling protects against ultraviolet-induced inflammation in vivo. Dong- Hun H Lee. 9:18 am, Poster #676
Raleigh Convention Center 307 Raleigh Convention Center Ballroom B/C Herman Beerman Lecture 9:40 am - 10:10 am Why Don’t We Get More Cancer: A Proposed Role of the Microenvironment in
Restraining Cancer Progression: Mina Bissell State-of-the-Art Plenary Lecture 3 10:15 am - 10:45 am Cytoskeletal Organization and Function in the Epidermis: Terry Lechler State-of-the-Art Plenary Lecture 4 10:45 am - 11:15 am Genomic Tracking of Microbial Pathogens: Julie Segre BCCNS Life Support Network 11:00 am - 1:00 pm Raleigh Convention Center 301 A/B Poster Session II/Technical Exhibits Open w/coffee break 11:15 am - 1:15 pm Even 002-286 / Odd 575-863 Raleigh Convention Center Exhibit Hall A Special: Poster session on Pediatric Dermatology led by Anu Mather 11:25-12:55 Meet by 11:25 inside the poster session to the left of the doorway
**Clinical Scholars Program 11:30 am - 1:30 pm Raleigh Convention Center 305 B 1. Neural recruitment and dynamism in the pathogenesis of atopic dermatitis. Ethan Lerner. 11:30 am, Poster #344 2. A novel therapeutic strategy for correcting the desquamation defects in Harlequin Ichthyosis. Dennis R Roop. 11:50 am, Poster #372 Role of IL-17 in Psoriasis and Other Skin Diseases: James Krueger Update on Atopic Dermatitis: Lisa Beck National Alopecia Areata Foundation 11:45 am - 1:30 pm Raleigh Convention Center 307 Genomic Technology Workshop 12:00 pm - 2:00 pm Raleigh Convention Center Ballroom B/C Welcome, Overview of Workshop, Introductions: Julie Segre Just Browsing—Demonstration of Online Browsers: Cristina de Guzman-Strong Technically Speaking Genomics—New Technology: Heidi Kong A Sequence of Events—Insights into Novel Gene Therapies: Keith Choate ChIP Away at the Unknown—Non-Coding DNA: Visualizing, Testing and Predicting: Kevin Wang Academic Dermatologists Luncheon 12:00 pm - 2:00 pm Sponsored by the Academic Dermatologists Committee of the Women’s Dermatology Society Raleigh Convention Center 302 B/C For all in academic dermatology programs (M.D. or Ph.D., male or female). Register through the WDS website (http://www.womensderm.org/events/2012-05-11_sid_raleigh.php) May 8th. Faculty members are encouraged to bring a trainee or two. Concurrent Minisymposia 2:00 pm - 5:30 pm
Immunology II: Innate Immunity and Microbiology Raleigh Convention Center 305 B Temporal shifts in the skin microbiome associated with atopic dermatitis disease flares and treatment. Heidi H Kong. 2:36 pm, Poster #665 The role of NOD-like receptor (NLR) signaling pathways in P. acnes’ induction of innate immune response. Min Qin. 3:00 pm, Poster #667 Dysregulation of the NKG2D axis in human and mouse alopecia areata. Zhenpeng Dai. 3:12 pm, Poster #668 Epidermal Toll-like receptor 2 (TLR2) enhances skin barrier recovery and its expression is decreased in atopic dermatitis. I-Hsin Kuo. 4:00 pm, Poster #637 Analysis of bacterial communities in hidradenitis suppurativa lesions. Natalia Vlassova. 4:12 pm, Poster #646 Deficiency in mouse beta-defensin 14 leads to a delay in skin permeability barrier repair. Nina Graumann. 4:24 pm, Poster #647 Distinct immune responses induced by lipoteichoic acid from S. aureus or S. epidermidis despite common pattern recognition pathways. Thomas Volz. 4:36 pm, Poster #660 Human Clinical Research and Therapeutics Raleigh Convention Center 306 C Hematopoietic and mesenchymal cell transplantation after myeloablative and non-myeloablative conditioning for recessive dystrophic and junctional epidermolysis bullosa (RDEB, JEB). Jakub Tolar. 2:00 pm, Poster #534 Efficacy and safety of vismodegib in advanced basal cell carcinoma. Anne Chang. 2:12 pm, Poster #546 Barrier enhancement for eczema prevention- the BEEP feasibility study. Eric L Simpson. 2:24 pm, Poster #529 Preliminary results of a Phase 2 trial evaluating efficacy and safety of vismodegib (GDC-0449) in operable basal cell carcinoma. Kenneth G Gross. 3:36 pm, Poster #543 Cross-sectional evaluation of biological markers of cardiovascular disease risk in children and adolescents with psoriasis. Wynnis L Tom. 4:00 pm, Poster #540 Imatinib mesylate for the treatment of sclerotic skin chronic graft-versus-host disease. Kristin Baird. 4:36 pm, Poster #518 Double-blind, randomized, bilateral comparison of skin irritancy following application of the combination acne products clindamycin/tretinoin and benzoyl peroxide/adapalene. Renato Goreshi. 4:48 pm, Poster #508 Epidermal Structure and Function Raleigh Convention Center 306 B Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development. Junko Okano. 2:00 pm, Poster #313 CXCR4 regulates lymphangiogenesis and keratinocyte proliferation in contact and IL23-mediated dermatitis. Tomonori Takekoshi. 2:12 pm, Poster #316 Beta-catenin is essential for complete epidermal barrier formation. Samriddha Ray. 2:24 pm, Poster #333
A novel therapeutic strategy for correcting the desquamation defects in Harlequin Ichthyosis. Lei Zhang. 2:36 pm, Poster #372 GPHR-dependent functions of the Golgi apparatus are essential for formation of lamellar granules and the skin barrier. Masahito Tarutani. 3:00 pm, Poster #320 The Trithorax complex promotes epidermal keratinocyte differentiation in part through GRHL3/GET1- mediated recruitment. Amelia Hopkin. 3:12 pm, Poster #354 Desmosomal cadherins crosstalk to the nucleus via a novel potent transcriptional regulator of the Wnt pathway: Plakoglobin (PG, JUP, γ-catenin). Arnaud Galichet. 3:24 pm, Poster #356 A novel human psoriatic skin reconstruct: The role of transit amplifying keratinocytes and of p75 neurotrophin receptor. Francesca Truzzi. 3:36 pm, Poster #310 KLK7 participates in the maturation of caspase-14 during keratinocyte terminal differentiation – Role of an intermediate form. Mami Yamamoto. 3:48 pm, Poster #341 Imaging mass spectrometry visualizes epidermal barrier ceramides and their immediate precursors. Naoko Goto-Inoue. 4:00 pm, Poster #317 Redundant roles of Ovol1 and Ovol2 transcription factors in epidermal morphogenesis. Briana Lee. 4:12 pm, Poster #363 Apoptosis of proliferating keratinocytes by targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with an anti-desmoglein monoclonal antibody. Michiyoshi Kouno. 4:24 pm, Poster #312 Neural recruitment and dynamism in the pathogenesis of atopic dermatitis. Sarina B Elmariah. 4:36 pm, Poster #344 Mandatory role of kallikrein 5 in profilaggrin maturation and possible association of its impairment with atopic dermatitis. Jun-ichi Sakabe. 4:48 pm, Poster #325
Carcinogenesis, Growth Factors, and Cancer Genetics Raleigh Convention Center 305 A SMO inhibitor effectiveness in a patient with a SHH locus translocation causing holoprosencephaly and basal cell carcinomas. Natalia Gomez-Ospina. 2:00 pm, Poster #167 Loss of Keratin 17 delays HPV-induced tumor growth in skin. Daryle Depianto. 2:12 pm, Poster #114
Nanodermatology Society 4:00 pm - 7:00 pm Raleigh Convention Center 302 A North American Hair Research Society Scientific Meeting 6:00 pm - 9:30 pm Raleigh Convention Center 302 B/C Galderma Japan Scientific Forum 6:30 pm - 9:30 pm Raleigh Convention Center 301 A/B Trainee Dinner Session 7:30 pm - 9:30 pm (encouraged for trainees – sign up in advance) Raleigh Convention Center Ballroom A SATURDAY, May 12, 2012
Raleigh Convention Center Ballroom B/C Plenary Session III 8:00 am - 9:00 am 1. Extracellular Hsp90alpha promotes human dermal fibroblast migration and skin wound healing via the NPTY motif within LRP-1 receptor and three downstream Akt kinases: Direct evidence for a cross-membrane signal transduction mechanism. F Tsen. 8:00 am, Poster #210 2. CXCL10, an IFN-γ-induced chemokine, is required for the development of depigmentation in a mouse model of vitiligo. Mehdi Rashighi. 8:12 am, Poster #001 3. The role of the microRNA miR-17~92 cluster in hair follicle biology. Thomas Andl. 8:24 am, Poster #466 4. Structural insight into the organization and function of keratin filaments. Chang-Hun Lee. 8:36 am, Poster #332 5. The role of voltage-gated calcium channels in controlling stem cells in non-excitable tissues. Gozde Yucel. 8:48 am, Poster #810
William Montagna Lecture 9:00 am - 9:30 am Genome Regulation by Long Noncoding RNAs: Howard Chang Julius Stone Lecture 9:30 am - 10:00 am The Hyper IgE Syndromes: Rebecca Buckley American Dermato-Epidemiology Network Business/Scientific Session 8:00 am - 12:00 pm Raleigh Convention Center 302 A Variation in dermatologist beliefs about the safety and effectiveness of treatments for moderate- to-severe psoriasis. Katrina Abuabara. 9:24 am, Poster #252 Interactions between adiposity and genetic polymorphisms on the risk of psoriasis. Wenqing Li. 9:36 am, Poster #287 Prevalence of comorbidities is lower among HLA-Cw6-positive psoriasis patients. Trilokraj Tejasvi. 9:48 am, Poster #270 Eczema severity is associated with multiple comorbid conditions and increased healthcare utilization. Jonathan I Silverberg. 10:00 am, Poster #260 Atopic dermatitis prevalence and co-morbidities in US women. Longde Lin. 10:12 am, Poster #273 Increasing sustainability of teledermatology practices: A study of operational models and challenges in modern-day teledermatology. April W Armstrong. 10:24 am, Poster #242 Poster Session III/Technical Exhibits Open w/coffee break 10:00 am - 12:00 pm Odd 289-573 / Even 576-864 Raleigh Convention Center Exhibit Hall A **Clinical Scholars Program 10:15 am - 12:15 pm Raleigh Convention Center Room 305 B Resident memory T cells are much more effective than central memory T cells in protection against viral skin infection. Thomas Kupper. 10:20 am, Poster #616 IL-15 is a therapeutic target in human alopecia areata. Angela Christiano.10:40 am, Poster #104 The Impact of High Throughput Sequencing in Genetic Skin Disease: David Kelsell Notch and SCC: Raymond Cho Concurrent Minisymposia 12:30 pm - 4:00 pm Pigmentation and Melanoma Raleigh Convention Center 306 B The dichotomous effects of IL-17 and TNF on normal human melanocytes may contribute to both hyper- and hypo-pigmentation associated with skin inflammation. Claire Q Wang. 1:06 pm, Poster #776 A mouse model of vitiligo with spontaneous epidermal depigmentation. Jonathan Eby. 1:18 pm, Poster #778 Keratinocyte p53, skin tanning and melanoma. Tamara Terzian. 1:30 pm,Poster #782
Genetic Disease, Gene Regulation and Gene Therapy Raleigh Convention Center 305 B TRIM32 regulates Th1/17 vs Th2 response to TLR activation, leading to psoriasis-like vs atopic dermatitis-like inflammatory diseases in mice. Yun Wang. 12:54 pm, Poster #428 Whole-exome sequencing in a single proband reveals a mutation in the CHST8 gene in autosomal recessive peeling skin syndrome. Mazen Kurban. 1:18 pm, Poster #426 Intravenously injected recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa. Xinyi Wang. 1:30 pm, Poster #419 Developing a stem cell-based therapy for epidermolysis bullosa simplex by promoting an allele specific knockout of mutant keratin 14 in induced pluripotent stem cells. Ganna Bilousova. 1:54 pm, Poster #434 CSA and CSB proteins localize in a large multiproteincomplex involved in repair and transcription of mitochondrial DNA: Involvement for neurodegeneration. York Kamenisch. 2:06 pm, Poster #388 Elucidation of the molecular basis of a novel osteocutaneous disease. Ofer Sarig. 2:18 pm, Poster #405 Cutaneous features of pseudoxanthoma elasticum in generalized arterial calcification of infancy due to ENPP1 gene mutations. Qiaoli Li. 2:30 pm, Poster #418 Recombinant filaggrin successfully internalized and processed in epidermal cells. Thomas Stout. 2:54 pm, Poster #389
Immunology I: Adaptive Immunity Raleigh Convention Center 305 A Treatment with Ruxolitinib, an orally bioavailable JAK1/2 inhibitor, prevents the onset of alopecia areata in C3H/HeJ mice. Zhenpeng Dai. 2:54 pm, Poster #626
VERSIÓN CONSOLIDADA DEL TRATADO DE FUNCIONAMIENTO DE LA UNIÓN EUROPEA ACTOS JURÍDICOS DE LA UNIÓN, PROCEDIMIENTOS DE ADOPCIÓN Y Artículo 288 (antiguo artículo 249 TCE) Para ejercer las competencias de la Unión, las instituciones adoptarán reglamentos, directivas, decisiones, recomendaciones y dictámenes. El reglamento tendrá un alcance general. Será obligatorio en todos sus e
In the early 1980s when the AIDS epidemic began, people living with HIV were not likely to live more than a few years. However, with the development of safe and effective drugs, HIV positive people now have longer and healthier lives. Currently available drugs do not cure HIV infection but they do prevent the development of AIDS. They can stop the virus being made in the body and this stops th