Microsoft powerpoint - jp005-2010_fluconacole_poster_finalcj

Comparable unbound fluconazole levels in plasma, lung
and soft tissue of healthy and septic rats
O. Mauric1, S. A. Kugler1, C. Thallinger2, S. M. Joukhadar1, C. Joukhadar1,3, F. Traunmüller1;
1J&P Medical Research Ltd., Vienna, Austria, 2Department of Internal Medicine I, Medical University Vienna, Vienna, Austria, 3Harvard Medical School, Objectives:
Methods:
Conclusion:
A total of 29 rats were included into this descriptive, In summary, we demonstrated that free concentration-vs.- fluconazole in the interstitium of healthy lung and skeletal controlled pharmacokinetic analysis. In 17 anesthetized time profiles of fluconazole in plasma are almost identical muscle after a single intravenous dose of 6 mg/kg. The healthy rats, thoracotomy, microdialysis probe insertion secondary objective was to explore whether severe into lung and skeletal muscle tissue and other study ventilated lung and skeletal muscle in healthy and experimental inflammation exerts significant effects on the related procedures were performed. In a total of 12 rats, inflamed conditions. Therefore, the concentration of time-concentration course of fluconazole.
Escherichia coli derived lipopolysaccharide (LPS) was fluconazole in plasma may serve as a good estimate for injected at an intraperitoneal dose of 250 µg and interstitial fluconazole concentrations in lung tissue and Results:
The pharmacokinetic profiles of fluconazole in lung and skeletal muscle tissue were descriptively almost identical to free concentration-versus-time profiles in plasma. No obvious difference in main pharmacokinetic parameters was detected between healthy rats and rats presenting response. Area under the concentration-vs.-time curve and infected plasma (n=17), 47.4 for healthy lung tissue (n=8), 39.1 for healthy muscle tissue (n=12), 52.9 for inflamed lung tissue (n=3) and 41.5 for inflamed muscle tissue (n=11). Corresponding values for C 8.4 for free healthy plasma, 11.0 for healthy lung tissue, 8.8 for healthy muscle tissue, 9.2 for inflamed free plasma, 11.8 for inflamed lung and 9.4 for inflamed muscle tissue. Half-lifes ranged between 12.3-22.4 h for Figures A-C: Pharmacokinetic profiles of fluconazole in plasma, inflamed and Contact Information: J&P MEDICAL RESEARCH
non-inflamed lung and muscle tissue in rats following single intravenous LTD. Center for Antiinfective Research.
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intraperitoneal injection of LPS from E. coli.
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Source: http://www.jp-medical-research.com/poster/pos032010.pdf