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The European Society for the Study of Diabetes (EASD) Natal, Rio Grande do Norte, Brazil, May 8-11, 2011 Scientific Program


17h00 -18h30 - Registration
18h45 - Welcome and opening remarks
Chairs - Carlos Boschero; Décio Eizirik

19h00 - Keynote Lecture
Genetics of type 2 diabetes- are we getting any closer?
Leif Groop, Lund University Diabetes Centre, Malmö, Sweden
20h00 – Welcome Cocktail


09h00 – 10h10 - Lectures
1 - Epigenetics and alternative splicing of beta cells in diabetes
Chairs - Leif Groop; Rui Curi
09h00 – 09h25 - The epigenome of pancreatic islets in health and disease –
François Fuks - Laboratory of Cancer Epigenetics, Université Libre de Bruxelles, (ULB),Belgium
09h35 – 10h00 - Alternative splicing in pancreatic beta cel s –
Decio L. Eizirik - Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Belgium
10h00 – 10h25 - Coffee break

10h25 – 11h45 - Short Talks
(8 min presentation + 4 min discussion)
OC.01
Functional and epigenetic alterations induced by palmitate in the insulin secreting clonal β cel line INS-1
832/13
Malmgren SM1; Nagorny CL1; Spegél P1; Dekker-Nitert M1; Ling C1; Mulder H1 - 1Lund University - Clinical
science, Malmö
OC.02
Relationships between pancreatic islets and clinical characteristics
Marselli L1; Suleiman M1; Bugliani M1; Marchetti P1 - 1University of Pisa - Department of Endocrinology
and Metabolism
OC.03
EFFECTS OF ANTI- AND PRO-INFLAMMATORY CYTOKINES ON THE EXPRESSION OF PRDX 6 IN INSULIN–
PRODUCING RINm5F CELLS
Paula FMM1; Souza KL2; Boschero AC3 - 1Department of Anatomy, Cel ular Biology and Physiology and
Biophysics - Institute of Biology, UNICAMP, Campinas, SP, Brazil; 2Institute of Biophysics Carlos Chagas
Filho - UFRJ, RJ, Brazil; 3Department of Anatomy, Cellular Biology and Physiology and Biophysics -
Institute of Biology, UNICAMP, Campinas, SP

OC.04
Non-obese diabetic mice deficient in the pro-apoptotic BH3-only protein Bid are protected from Fas-
induced beta cel destruction but not diabetes
Mol ah Z1; Kay T1; Thomas H1 - 1St Vincents Institute - Immunology and Diabetes
OC.05
Global gene expression profiling to identify the mechanisms involved in the protective effects of 1,25-
dihydroxyvitamin D3 against cytokine-induced damage of islets of Langerhans.
Wolden-Kirk H1; Overbergh L2; Van Lommel L3; Naamane N4; Gysemans C2; Brusgaard K1; Christesen
HB1; Thorrez L5; Schuit F3; Eizirik DL4; Mathieu C2 - 1University of Southern Denmark - Inst. of Clinical
Research; 2Catholic University of Leuven - Experimental Medicine; 3K.U.Leuven - Gene Expression
Unit; 4Université Libre de Bruxelles - Experimental Medicine; 5Catholic University of Leuven - Stem Cell
Institute Leuven
OC.06
Differential Role of GPRC5B and GPRC5C Receptors in the Regulation of Pancreatic β-cel Function
Soni A1; stefan A2; Sarheed JM3; P Rorsman4; Salehi A1 - 1Lund university - Clinical Science; 22The Oxford
Centre for Diabetes - Endocrinology & Metabolism, Oxford University, UK; 3Lund University -
Department of Clinical Science, UMAS, Clinical Research Center, University of Lund, Sweden; 4The
Oxford Centre for Diabetesm, Oxford University, UK - Endocrinology & Metabolism
11h45 – 13h00 – Poster Session

PT.01
Islet changes induced by increased fructose intake: increased β-cel apoptosis and islet fat deposit.
Rebol edo OR1; Marra CA2; Del Zotto H3; Borel i MI4; Maiztegui B5; Gagliardino JJ6 - 1Facultad de Ciencias
Médicas UNLP - CENEXA (UNLP-CONICET; 2Facultad de Ciencias Médicas UNLP - INIBIOLP (UNLP-
CONICET; 3CENEXA (UNLP-CONICET LA PLATA) - Fac. Cs. Médicas UNLP; 4Universidad Nacional de La
Plata - Centro de Endocrinología Experimental y Aplicada (CENEXA); 5CENEXA - Facultad de Ciencias
Medicas; 6CENEXA (UNLP-CONICET) - Facultad de Ciencias Médicas UNLP
PT.02
Islet Neogenesis-Associated Protein (INGAP): Its Positive Physiological Modulatory Role in Insulin
Secretion
Flores LE1; Del Zotto H1; Raschia MA1; Borel i MI1; Barbosa HC2; Boschero AC3; Gagliardino JJ1 - 1CENEXA
(UNLP-CONICET LA PLATA) - Fac. Cs. Médicas UNLP; 2UNICAMP - Departamento de Fisiologia e
Biofísica; 3IB - UNICAMP - Fisiologia e Biofísica
PT.04
Placental VEGF, COX-2 and CASPASE-3 in pregnancies complicated by diabetes or mild gestational
hyperglycemia, relation with hyperglycemia and umbilical PI
Saito FH1; Calderon IMP1; Carvalho-Silva SAL1; Moreli JB1; Amorin RL2; Damasceno DC1; Rudge MVC1 -
1Botucatu Medical School/UNESP - Gynecology and Obstetrics; 2School of Veterinary Medicine and
Animal Sciences/UNESP - Pathology
PT.05
Reduction of SIRT4 protein expression impairs glucose-stimulated insulin secretion in islets from both
control and restricted rats
Alves P L1; Vanzela EC2; Ribeiro RA2; Barbosa HC2; Amaral MEC1 - 11Centro Universitário Hermínio
Ometto, Programa de Pós Graduação em Ciências Biomédicas, UNIARARAS - NUCISA; 2UNICAMP -
Fisiologia e Biofísica
PT.06
Effect of Azadirachta indica (Neem) seed oil on maternal-fetal outcomes, lipid profile and oxidative
stress in streptozotocin-induced diabetic rats
Iessi IL1; Dal aqua B2; Saito FH3; Corvino SB4; Piculo F1; Calderon IMP5; Lima PHO6; Rudge
MVC7; Rodrigues T8; Damasceno DC9 - 1Unesp - Botucatu - Ginecologia e Obstetrícia; 2Unesp - Botucatu -
Ginecologia e Obstetricia; 3Faculdade de Medicina de Botucatu - UNESP - Ginecologia e
Obstetrícia; 4Faculdade de Medicina de Botucatu - Ginecologia e Obstetrícia; 5FMBotucatu/UNESP -
Ginecologia e Obstetrícia; 6UNESP - Faculdade de Medicina de Botucatu/ UNOESTE-Universidade do
Oeste Paulista - Ginecologia e Obstetrícia/ FACLEPP; 7UNESP - Ginecologia e Obstetrícia; 8Universidade
de Mogi das Cruzes - Centro Interdisciplinar de Investigação Bioquímica; 9Faculdade de Medicina de
Botucatu, Unesp, São Paulo, Brasil - Programa de Pós-Graduação em Ginecologia, Obstetrícia e
Mastologia
PT.07
KNOCKDOWN OF 5-HT2B RECEPTOR DECREASE GLUCOSE STIMULATED INSULIN SECRETION IN A CLONAL
(INS (832/13) BETA-CELL LINE
Bennet H1; Nagorny CL2; Wierup N3; Dekker-Nitert M4; Lernmark A1; Fex M1 - 1Clinical science, Malmö -
The unit of Diabetes and Celiac disease; 2Clinical science, Malmö - Molecular Metabolism; 3Clinical
science, Malmö - Neuroedocrine Cel Biology; 4Clinical science, Malmö - Diabetes and Endocrinology
PT.08
ARHGAP21 expression in MIN6 cel s and neonatal pancreatic islets: possible participation on the
mechanism of insulin secretion
Ferreira SM1; Barbosa HC2; Rezende LF3; Bigarella CL4; Saad ST5; Boschero AC6 - 1Universidade Estadual
de Campinas - Anatomia, Biologia Celular e Fisiologia e Biofísica; 2UNICAMP - Departamento de
Fisiologia e Biofísica; 3Universidade Estadual de Campinas - UNICAMP - Departamento de Anatomia,
Biologia Celular e Fisiologia e Biofísica; 4UNICAMP - Hemocentro; 5UNICAMP - Centro de Hematologia e
Hemoterapia; 6IB - UNICAMP - Fisiologia e Biofísica
PT.09
Calcium signaling alteration is associated with mitochondrial dysfunction and increased ROS generation
in the islets of Langerhans from senescent rats
Coelho F. M.1; Sinigaglia-Coimbra R2; Hirata AE3; Jurkiewicz A4; Smaili SS5; Lopes GS4 - 1UNIFESP -
Departamento de Farmacologia; 2Universidade Federal de São Paulo - Medicina; 3UNIFESP - EPM -
Fisiologia ; 4UNIFESP - EPM - Farmacologia; 5UNIFESP - EPM - Farmacologia - MAD
PT.10
Evaluation of azadirachtin effect in streptozotocin-induced diabetic rats during pregnancy
Damasceno DC1; Dal aqua B2; Iessi IL3; Saito FH4; Bueno A5; Netto AO6; Sinzato YK7; Marini G6; Rudge
MVC7; Rodrigues T8 - 1FM - UNESP - Botucatu - Ginecologia e Obstetrícia; 2Unesp - Botucatu -
Ginecologia e Obstetricia; 3UNESP - Ginecologia e Obstetricia; 4Faculdade de Medicina de Botucatu -
UNESP - Ginecologia e Obstetrícia; 5Faculdade de Medicina de Botucatu UNESP - Ginecologia e
Obstetrícia; 6Faculdade de Medicina de Botucatu - Ginecologia e Obstetrícia; 7UNESP - Ginecologia e
Obstetrícia; 8Universidade de Mogi das Cruzes - Centro Interdisciplinar de Investigação Bioquímica
PT.11
GLUCOSE TOLERANCE, INSULIN SECRETION AND CA2+ HANDLING IN ISLETS FROM LDL RECEPTOR
KNOCKOUT MICE (LDLR-/-) FED HIGH-FAT-DIET (WESTERN-TYPE)
Souza JC1; Vanzela EC1; Ribeiro RA1; Machado-de-Oliveira CAM2; Oliveira HCF1 - 1UNICAMP - Anatomia,
Biologia Celular, Fisiologia e Biofísica; 2Unifesp - Biociências
PT.12
Chronology of appearance of INGAP-positive cells and its relationship with the increase in B-cel mass
during the pre and postnatal periods
Madrid V1; Borel i MI2; Maiztegui B1; Boschero AC3; Barbosa HC4; Gagliardino JJ2; Del Zotto H1 - 1CENEXA
(UNLP-CONICET LA PLATA) - Fac. Cs. Médicas UNLP; 2Universidad Nacional de La Plata - Centro de
Endocrinología Experimental y Aplicada (CENEXA); 3IB - UNICAMP - Fisiologia e Biofísica; 4UNICAMP -
Departamento de Fisiologia e Biofísica
PT.13
Effects of Fatty Acids Withdrawal in Culture Medium on RINm5F Cel s Death Susceptibility
Rosim MP1; Nunes, V. A.2; Lenzen S3; Curi R4; Azevedo-Martins AK5 - 1Universidade de São Paulo -
ICB; 2Universidade de São Paulo - Escola de Artes, Ciências e Humanidades; 3MHH-Hannover - Klinische
Biochemie; 4ICB - USP - Fisiologia e Biofísica; 5Universidade de São Paulo - Escola de Artes Ciências e
Humanidades
PT.14
PROTEIN RESTRICTION DURING PREGNANCY DID NOT MODIFY PRO-APOPTOTIC GENES EXPRESSION,
BUT IMPAIRED THE EXPANSION OF PANCREATIC ISLETS AREA
Ramalho AFS1; Salvatierra CB2; Reis SRL1; Lemes SF1; Veloso RV1; Marise ABReis3; Arantes VC1; Latorraca
MQ4 - 1Universidade Federal de Mato Grosso - Departamento de Alimentos e Nutrição; 2UNEMAT -
Departamento de Engenharia de Alimentos; 3Universidade Federal de Mato Grosso - Departamento de
Ciências Básicas em Saúde - FCM/UFMT; 4Universidade Federal de Mato Grosso, Faculdade de Nutrição -
Departamento de Alimentos e Nutrição
PT.15
Proteomic Approach to Search for Differential y Expressed Proteins in Human Pancreatic Islets and
Human Insulinomas.
Terra L. F.1; Teixeira PC2; Wailemann R. A.1; Zelanis A.3; Palmisano G.4; Cunha-Neto E2; Kalil J2; Sogayar
MC1; Labriola L1 - 1Instituto de Química - USP - Bioquímica; 2InCor - FM - USP - Clínica Médica - Disciplina
de Imunologia Clínica e Alergia / Lab de Imunologia; 3Instituto Butantã - CAT- CEPID; 4University of
Southern Denmark - Biochemistry and Molecular Biology
PT.16
CaMK4/CREB pathway-mediated β-cel proliferation
Barbosa HC1; Rodrigues de Ledesma AM1; Liu B1; Jones PM1; Persaud SJ1; Mul er DS1 - 1King Col ege
London - Diabetes and Nutritional Sciences Division
PT.17
CYTOTOXICITY AND CYTOPROTECTIVE EFFECTS OF FLAVONOIDS RUTIN, HESPERIDIN, NARINGIN,
NEOHESPERIDIN ON INSULIN-SECRETING CELLS BRIN-BD11.
FELIPE ET1; MAESTRI JS1; KANUNFRE CC2; GRASSIOLLI S2; Curi R3; Newsholme P4; Carpinelli AR5; Oliveira-
Emilio HR2 - 1Universidade Estadual de Ponta Grossa - Mestrado em Biologia Evolutiva; 2Universidade
Estadual de Ponta Grossa - Biologia Geral; 3ICB - USP - Fisiologia e Biofísica; 4University Col ege Dublin -
School of Biomolecular and Biomedical Science; 5USP - Fisiologia e Biofísica
PT.18
MORPHOMETRY OF ENDOCRINE PANCREAS IN THE MSG-OBESE RAT
Lubaczeuski, C1; Vettorazzi JF2; Ferreira, LE1; Ribeiro RA4; Bonfleur ML3; Balbo SL1 - 1UNIOESTE -
CCBS; 2Unicamp - Anatomia, Biologia celular e Fisiologia e Biofísica; 3UNIOESTE - Centro de Ciências
Biológicas e da Saúde; 4Universidade Estadual de Campinas - Fisiologia e Biofísica
PT.19
CONDITIONAL EXPRESSION OF CONSTITUTIVELY ACTIVE EGF-R IN BETA CELLS
Hakonen E1; Ustinov J1; Miettinen P1; Otonkoski T1 - 1University of Helsinki - Biomedicum Stem Cell
Center and Hospital for Children and Adolescents
PT.20
Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cel s and mouse islets.
MARROQUI L1; Vieira E1; Gonzalez A1; Nadal A1; Quesada I1 - 1Universidad Miguel Hernández, Spain. -
Instituto de Bioingeniería.
PT.21
NADPH oxidase plays an active role in the changes induced by fructose upon islet function
Borel i MI1; Flores LE1; Raschia MA2; Román L2; Rebol edo OR2; Gagliardino JJ3 - 1CENEXA (UNLP-CONICET
LA PLATA) - Fac. Cs. Médicas UNLP - ARGENTINA; 2CENEXA (UNLP-CONICET LA PLATA) - Fac. Cs. Médicas
UNLP - ARGENTNA; 3CENEXA (UNLP-CONICET LA PLATA) - Fac. Cs. Médicas UNLP - ARGENTINA

PT.22
Intrauterine Growth Retardation together with High Fat Diet in Rats Markedly Disturbs Islet Morphology
without Loss of Beta-cel Mass or Induction of Diabetes
Delghingaro-Augusto V1; Madad L1; Simeonovic C1; Dahlstrom JE1; Nolan C1 - 1Australian National
University - Medical School
PT.23
Participation of NAD(P)H oxidase on insulin secretory process of BRIN-BD11 beta cel s.
Hirata AE1; Morgan D2; Graciano MFR3; Curi R4; Carpinel i AR3; Flatt, PR5; Newsholme P6 - 1UNIFESP -
EPM - Fisiologia; 2USP - Fisiologia e Biofísca; 3USP - Fisiologia e Biofísica; 4ICB - USP - Fisiologia e
Biofísica; 5University of Ulster - School of Biomedical Sciences; 6University College Dublin - School of
Biomolecular and Biomedical Science
PT.24
Protzek AOP1; Costa Júnior JM1; Purificação TA1; Rafacho A2 - 1State University of Campinas - Unicamp -
Department of Anatomy Physiology and Biophysics, Institute of Biology; 2Universidade Federal de
Uberlândia - Faculdade de Ciências Integradas do Pontal
13h00 – 15h00 – Lunch time
May , Monday 9th
15h30 – 17h15 - Lectures
2 - Cross talk between beta-cells and other cells/-tissues
Chairs - Anders Tengholm; Jens Nielsen
15h30 – 15h55 - Connecting cel s within the islets
Paolo Meda – University of Geneva School of Medicine, Switzerland
16h05 – 16h30 - Hypothalamic inflammation connecting obesity to pancreatic islet failure –Lício
Augusto Velloso – School of Medical Sciences (UNICAMP), Campinas, SP, Brazil
16h40 – 17h05 - Modulation of pancreatic β-cel metabolism and insulin secretion by IL-6 released from
skeletal muscle
Philip Newsholme UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, UCD
Dublin, Dublin 4, Ireland
17h15 – 17h30 h - Coffee break

17h30 – 18h30 h - Short Talks
(8 min presentation + 4 min discussion)
OC.07
Functional changes of pancreatic beta cel s by high a glucose diet and hyperfunction of adipocytes
Velasco M1; Larque C1; MHiriart-Urdanivia2 - 1Instituto de Fisiologia Celular, UNAM - Neurodevelopment
and Physiology; 2Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, UNAM -
Neurodevelopment and Physiology
OC.08
The use of proteomics to elucidate the protective effects of glucagon-like peptide-1 on cytokine-
mediated beta-cel dysfunction and death.
Overbergh L1; Bugliani M2; De Hertog W1; Verdrengh E1; Masini M3; Waelkens E4; Marchetti P5; Mathieu
C1 - 1Catholic Unversity of Leuven - Laboratory of Experimental Medicine and Endocrinology; 2 -
3University of Pisa - Endocrinology and Metabolism; 4Catholic Unversity of Leuven - Laboratory of
Protein Phosphorylation and Proteomics; 5University of Pisa - Dept. Endocrinology and Metabolism
OC.09
Lipotoxic ER stress-induced DP5 and PUMA expression contributes to mitochondrial beta-cel apoptosis
Cunha DA1; Gurzov EN1; Germano C2; Naamane N1; Eizirik DL1; Cnop M1 - 1Université Libre de Bruxel es -
Experimental Medicine; 2Faculdade de Medicina de Ribeirão Preto - Clínica Médica
OC.10
The role of GPR40 in type 2 diabetes and obesity in animal models
Balhuizen A1; Kumar R2; Salehi A3 - 1Lund university, Sweden - Clinical Science; 2Lund university - Clinical
Science; 3Lund University - Clinical Sciences
OC.11
Role of the Ubiquitin-Proteasome System (UPS) in Type 2 Diabetes (T2D) Beta Cell Dysfunction.
Bugliani M1; R Liechti2; Cheon H3; Marsel i L4; Suleiman M1; Xenarios I2; Lee M.S.3; Marchetti P1 -
1University of Pisa - Dept. Endocrinology and Metabolism; 2Swiss Institute of Bioinformatics - Vital-It group; 3Samsung Biomedical Center - Department of Medicine; 4University of Pisa - Department of Endocrinology and Metabolism
09h00 – 10h45 h - Lectures
3 - The role for diabetes candidate genes in pancreatic beta cells
Chairs - Miriam Cnop; Fumihiko Urano
09h00 – 09h25- From genotype to pancreatic β-cel phenotype in humans –
Piero Marchetti, Cisanel o Hospital, Pisa - Italy
09h35 – 10h00 - Translating genome wide association signals into molecular mechanisms for diabetes in
human pancreatic islets
Anna L Gloyn - Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, UK
10h10 – 10h35 Impact of natural y occurring severe activating glucokinase mutation gene in human
islets –
Antonio Luís Cuesta Muñoz - Center for the Study of Pancreatic Beta-cell Diseases-DRI-Málaga, IMABIS-
Carlos Haya Foundation, Malaga, SPAIN
10h45 – 11h00 - Coffee break

11h00 – 11h50 - Short Talks
(8 min presentation + 4 min discussion)
OC.12
Differential usage of NF-kB activating signals by IL-1β and TNF-α in pancreatic beta cel s
Ortis F1; Miani M2; Col i ML2; Cunha DA2; Gurzov EN2; Allagnat F2; Eizirik DL2 - 1Université Libre de
Bruxel es, Brussels, Belgium - Experimental Medicine - Institute of Biology, State University of Campinas
(UNICAMP), Campinas, SP, Brazil - Anatomy, Cel ular Biology and Physiology and Biophysics; 2Université
Libre de Bruxelles, Brussels, Belgium - Experimental Medicine
OC.13
Role of melatonin receptors in pancreatic islets
Nagorny CL1; Bennet H1; Stamenkovic J1; Sathanoori R1; Fex M1; Wierup N1; Mulder H1 - 1Lund
University - Clinical Sciences Malmö
OC.14
Growth arrest specific protein 6 impinge on the β-cell mass in the newborn rat
Haase TN1 - 1University of Copenhagen - Department of Biomedical Sciences
OC.15
Mechanisms of expansion of the beta-cell mass in pregnancy
Gaarn LW1; Nielsen JH1 - 1Faculty of Health Sciences, University of Copenhagen - Department of
Biomedical Sciences
11h50 – 13h30 – Poster Session 2
PT.25
Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum
Ca2+ stores and triggers apoptosis in pancreatic b-cel s.
Herchuelz A1 - 1Laboratoire de Pharmacodynamie - ULB, Belgium
PT.26
Effect of INGAP-PP upon islet glucokinase activity and glucose metabolism
Maiztegui B1; Borelli MI1; Gagliardino JJ1 - 1CENEXA (UNLP-CONICET La Plata) - Facultad de Ciencias
Médicas-UNLP
PT.27
Identification of a novel GPCR mediating anti-diabetic effects of AAT
Kumar R1; Balhuizen A2; Soni A1; Salehi A1 - 1Lund university - Clinical Science; 2Lund University, Sweden -
Clinical Sciences
PT.28
Tumor necrosis factor-alpha and interferon-gamma induce pancreatic beta cel apoptosis through
STAT1-mediated Bim activation
Gurzov EN1; Barthson J1; Germano C2; Moore F1; Eizirik DL1 - 1Université Libre de Bruxelles -
Experimental Medicine; 2Faculdade de Medicina de Ribeirão Preto - Clínica Médica
PT.29
Maternal protein restriction leads functional changes in pancreatic islets M2/3 subtype of muscarinic
receptor (mAChR) from adult rats.
de Oliveira JC1; Barel a LF2; Branco RCS2; Miranda RA2; Bataglini LA2; Lepri ER3; Mel o EVSL3; Gravena
C2; Mathias PCF2 - 1Universidade Estadual de Maringá - UEM - Biogia Celular e Genética; 2Universidade
Estadual de Maringá - UEM - Biologia Celular e Genética; 3Universidade Estadual de Maringá - UEM -
Histologia
PT.30
Impaired insulin secretory response in obese rats involves reduced muscarinic receptor function of
pancreatic islets and high parasympathetic activity
Branco RCS1; Grassiol i S2; Bataglini LA3; Miranda RA4; Gravena C3; Mello E5; Lepri ER5; Mathias PC3; de
Oliveira JC6 - 1Universidade Estadual de Maringa - Biologia Celular e Genetica; 2UEM - DBC; 3UEM -
Biologia Celular e Genética; 4UEM - Biologia Celular; 5UEM - Histologia; 6Universidade Estadual de
Maringá - Biologia Celular e Genética
PT.31
BISPHENOL-A EXPOSURE DURING PREGNANCY DISRUPTS GLUCOSE HOMEOSTASIS IN MOTHERS AND
ADULT MALE OFFSPRING
Alonso-Magdalena P1; García-Arévalo M1; Vieira E1; Soriano S1; Menes L2; Burks D2; Quesada I1; Nadal A1
- 1Universidad Miguel Hernández - Instituto de Bioingeniería; 2Instituto Principe Felipe - CSIC
PT.32
MALNUTRITION AFTER WEANING IMPAIRS THE PROTECTIVE EFFECT OF TAURINE (TAU)
SUPPLEMENTATION UPON ENERGY BALANCE, GLUCOSE HOMEOSTASIS AND INSULIN SECRETION (IS) IN
MICE FED A HIGH FAT DIET (HFD)
Camargo RL1; Cappel i APG2; Batista TM2; MR Silva P3; Ribeiro RA4; Zoppi CC5; Carneiro EM5 -
1Universidade Estadual de Campinas - UNICAMP - Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica; 2Unicamp - Fisiologia e Biofísica; 3Unicamp - Fisiologia; 4Universidade Estadual de
Campinas - Fisiologia e Biofísica; 5UNICAMP - Anatomia, Biologia Celular e Fisiologia e Biofísica
PT.33
Reduction of plasma lipids improves insulin secretion in insulin resistant rats.
Destro M1; Bosqueiro JR1 - 1FC - UNESP - Bauru - Educação Física
PT.35
Endoplasmic Reticulum Stress: a potential candidate for the gestational diabetes pathogenesis
Nunes, V. A.1; Araujo MS2; Rosim MP3; Curi R4; Azevedo-Martins AK5 - 1Universidade de São Paulo -
Escola de Artes, Ciências e Humanidades; 2UNIFESP - Bioquímica; 3Universidade de São Paulo - Fisiologia
e Biofísica; 4ICB - USP - Fisiologia e Biofísica; 5Universidade de São Paulo - Escola de Artes Ciências e
Humanidades
PT.36
SNARE COMPLEX FORMATION IN PANCREATIC ISLETS OF RATS SUBMITTED TO PROTEIN MALNUTRITION
Lopes BV1; Bertuol AEM1; Dotto RP1; Sílvia RLReis2; Arantes VC3; Latorraca MQ4; Marise ABReis5 -
1Universidade Federal de Mato Grosso - Departamento de Alimentos e Nutrição; 2Universidade Federal
de Mato Grosso - Laba; 3UFMT - Alimentos e Nutrição; 4Universidade Federal de Mato Grosso, Faculdade
de Nutrição - Departamento de Alimentos e Nutrição; 5Universidade Federal de Mato Grosso -
Departamento de Ciências Biológicas da Saúde - Fisiologia
PT.37
DIFFERENTIAL IMPACT OF CHRONICALLY ELEVATED GLUCOSE AND PYRUVATE LEVELS ON THE
MITOCHONDRIAL AND PLASMA MEMBRANE IN BETA CELLS
Goehring I1; Malmgren SM1; Mulder H1; Nichol s D2 - 1Lund University Diabetes Centre - Department of
Clinical Sciences, Malmö, Sweden; 2Buck Institute for Age Research - Novato, United States
PT.38
TNF-α AND ADIPONECTIN LEVELS RELATED TO BODY MASS INDEX IN MILD GESTATIONAL
HYPERGLYCEMIA
Bueno A1; Sinzato YK2; Lima PHO3; Moreli JB4; Caetano M5; Gelaleti RB6; Morceli G7; Damasceno
DC8; Calderon IMP9; Rudge MVC2 - 1Faculdade de Medicina de Botucatu UNESP - Ginecologia e
Obstetrícia; 2UNESP - Ginecologia e Obstetrícia; 3UNESP - Faculdade de Medicina de Botucatu/
UNOESTE-Universidade do Oeste Paulista - Ginecologia e Obstetrícia/ FACLEPP; 4Faculdade de Medicina
de Botucatu- Unesp-Botucatu - Ginecologia Obstetrícia e Mastologia; 5Universidade Estadual Paulista -
UNESP - Ginecologia e obstetrícia; 6UNESP - FMB - Ginecologia e Obstetrícia; 7Faculdade de Medicina de
Botucatu-Júlio de Mesquita Filho/FMB/UNESP - Departamento de Ginecologia e Obstetrícia; 8Faculdade
de Medicina de Botucatu, Unesp, São Paulo, Brasil - Programa de Pós-Graduação em Ginecologia,
Obstetrícia e Mastologia ; 9FMBotucatu/UNESP - Ginecologia e Obstetrícia
PT.39
TAURINE AMELIORATES GLUCOSE HOMEOSTASIS AND PANCREATIC ISLET FUNCTION IN OBESE (ob/ob)
MICE
Santos-Silva, JC1; Ribeiro RA1; Cotrim, BB1; Carneiro EM1 - 1State University of Campinas - Department of
Anatomy, Cel Biology and Physiology and Biophysics
PT.40
EFFECTS OF EXERCISE TRAINING AND INTERLEUKIN 6 UPON INSULIN SECRETORY MACHINERY PROTEINS:
EVIDENCE FOR A POSSIBLE CONTRACTING SKELETAL MUSCLE AND PANCREATIC β-CELLS CROSSTALK
MODULATION
Zoppi CC1; Costa Jr. JM1; Paula FMM1; Machado-de-Oliveira CAM2; Silveira LR3; Carneiro EM4 - 1State
University of Campinas - Anatomy, Cel ular Biology and Physiology and Biophysics; 2Unifesp -
Biociências; 3USP - Ribeirão Preto - Escola de Ed Física; 4UNICAMP - Fisiologia e Biofísica
PT.41
EARLY SWIM TRAINING MODULATES GLUCOSE AND CHOLINERGIC RESPONSES IN PANCREATIC ISLETS
FROM MSG-OBESE RATS
Borck, P.C.1; Rickli, S.2; Barros, V.B.3; Franco, A.H.3; Alípio, J.C. de L.2; Venturel i, A.C.3; Machado,
M.J.R.2; Leite, N. de C.3; Gonçalves, D.C.de O.N.1; Mathias PCF4; Grassiol i S5 - 1UEPG - Farmácia; 2UEPG -
Enfermagem; 3UEPG - Educação Física; 4UEM - Biologia Celular e Genética; 5UEPG - DeBio
PT.42
Alpha 1-antitrypsin protects mouse islets from LPS induced inflammation
Nal a AA1; Nielsen JH1; Nal a A1; Bil estrup N1; Frøkiær H2; Metzdorff S2; Petersen M2; Mehlsen A2; Shah
F3 - 1Faculty of Health Sciences, University of Copenhagen - Biomedical Institute; 2Faculty of Life
Sciences, University of Copenhagen - Biochemistry; 3DTU Nanotech, Lyngby - Department of Micro- and
Nanotechnology
PT.43
CILIARY NEUROTROPHIC FACTOR (CNTF) IMPROVES INSULIN SECRETION AND HALF-LIFE AND INCREASES
INSULIN SENSITIVITY IN NON-OBESE DM2 MICE
Rezende LF1; Santos GJ2; Santos-Silva, JC2; Boschero AC2 - 1State Universiy of Campinas - Department of
Anatomy, Cel Biology and Physiology and Biophysics; 2State University of Campinas - Department of
Anatomy, Cel Biology and Physiology and Biophysics
PT.44
EFFECT OF THE PHYSICAL EXERCISE IN THE MECHANISMS OF THE SECRETION INSULIN IN MSG-OBESE
MICE EFFECT OF THE PHYSICAL EXERCISE IN THE MECHANISMS OF THE SECRETION INSULIN IN MSG-
OBESE MICE
Picinato MC1 - 1USP - Departamento de Fisiologia e Biofísica
PT.45
Insulin Secretion in Obese and Diabetic Animals Induced by High Fat Diet (HFD): The Role of Interleukin
10 (IL-10).
Cintra DE1; Pauli JR1; Ropelle ER1; Morarij J2; Contin Moraes J3; Araujo EP4; de Souza CT5; Batista
TM6; Carneiro EM6; Saad MJA7; Velloso LA7 - 1Universidade Estadual de Campinas - Faculdade de
Ciências Aplicadas; 2Unicamp - Faculdade de Ciências Médicas; 3Universidade Estadual de Campinas -
Faculdade de Ciências Médicas; 4FCM UNICAMP - Enfermagem; 5FCM - UNICAMP - Clínica
Médica; 6Unicamp - Fisiologia e biofísica; 7UNICAMP - Clínica Médica
PT.46
LOW PROTEIN DIET DURING FETAL LIFE AND NUTRITIONAL RECOVERY AFTER BIRTH WITH HIGH-FAT
DIET IN RATS: EFFECTS ON INSULIN SECRETION
Silva HBF1; CARDOSO KB2; CARLI AP3; Reis SRL2; Souza LMI4; Marise ABReis5; Latorraca MQ6; Milanski
M7; Arantes VC2 - 1Universidade Federal de Mato Grosso - Pós-Graduação em Biociências; 2Universidade
Federal de Mato Grosso - Departamento de Alimentos e Nutrição, Faculdade de
Nutrição; 3Universdidade Federal de Mato Grosso - Pós-graduação em Biociências; 4Universidade
Estadual de Campinas - Programa de Pós Graduação em Fisiopatologia Médica; 5Universidade Federal de
Mato Grosso - Departamento de Ciências Básicas, Faculdade de Ciências Médicas; 6Universidade Federal
de Mato Grosso, Faculdade de Nutrição - Departamento de Alimentos e Nutrição; 7Unicamp -
Departamento de Clínica Médica
PT.47
DUODENAL-JEJUNAL BYPASS IMPROVES GLUCOSE HOMEOSTASIS IN OBESE RATS
Araujo, ACF1; Balbo SL2; Ribeiro RA3; Nardel i TR4; Vettorazzi JF4; Bonfleur ML5 - 1UNIOESTE -
CCMF; 2UNIOESTE - CCBS; 3Universidade Estadual de Campinas - Fisiologia e Biofísica; 4Unicamp -
Anatomia, Biologia celular e Fisiologia e Biofísica; 5UNIOESTE - Centro de Ciências Biológicas e da Saúde
PT.48
Dexamethasone treatment increases AS160 activity in rat pancreatic islets through AMPK and AKT
pathways
Purificação TA1; Paula FM1; Rezende LF1; Protzek AO1; Rafacho A2 - 1Unicamp – State University of
Campinas - Department of Anatomy Physiology and Biophysics, Institute of Biology; 2Federal University
of Santa Catarina - bDepartment of Physiological Sciences, Center of Biological Sciences
13h30 – 15h00 – Lunch time


15h30 – 17h15 - Lectures
4 - New developments in the regulation of islet cell function
(chair - André Herchuelz; Ângelo Carpinel i)
15h30 – 15h55 - Metabolic regulation of glucagon secretion –
Quan Zhang– The Oxford Centre for diabetes, Oxford, UK
16h05 – 16h30- The clock gene Rev-erb-alpha regulates beta cel function: modulation by high fat diet
and leptin
Elaine Vieira - Instituto de Bioingeniería, Universidad Miguel Hernandez, Elche, Spain
16h40 – 17h05 - Rho GTPases in insulin secretion
Anjan Kowluru – Department of Pharmaceutical Sciences and Internal Medicine, Wayne State University
and John D Dingel VA Medical Center, Detroit, MI48201, USA
17h15 – 17h30 - Coffee break

17h30 – 18h20 - Short Talks
( 8 min presentation + 4 min discussion)
OC.16
The Ca2+-activated cation channel TRPM5 as a positive regulator of insulin release.
Colsoul B1; Schraenen A2; Gilon P3; Nilius B1; Schuit F2; Vennekens R1 - 1K.U.Leuven - Laboratory of Ion
Channel Research; 2K.U.Leuven - Gene Expression Unit; 3UCL - Pôle d’Endocrinologie, Diabète et
Nutrition
OC.17
AMPK-UCP2 pathway may be involved in the reduced insulin secretion by pancreatic islet of low protein
fed mice
de Oliveira CA1; Rezende LF2; Vanzela EC2; Santos GJ2; Souza JC2; Calegari VC2; Costa Júnior JM2; Protzek
AO2; Carneiro EM2 - 1Universidade Federal de São Paulo - Unifesp - Departamento de
Biociências; 2Universidade Estadual de Campinas - UNICAMP - Departamento de Anatomia, Biologia
Celular e Fisiologia e Biofísica
OC.18
Regulation of Epac2 localization in β-cel s by cAMP and Ca2+-mediated activation of Ras
Tengholm A1; Ideval -Hagren O1 - 1Uppsala University - Department of Medical Cell Biology
OC.19
Simvastatin treatment inhibits glucose-stimulated insulin secretion in INS-1E cel s
Zúñiga JP1; Rebelato ELO2; Abdulkader F3 - 1Instituto de Ciências Biomédicas, Universidade de São
Paulo - Fisiologia e Biofísica; 2ICB - USP - Fisiologia e Biofísica; 3ICB-USP - Fisiologia e Biofísica

08h00 – 09h45 - Lectures
5 - Beta cell proliferation & regeneration
chairs - Sigurd Lenzen; Anna Gloyn
08h00 – 08h25 - Role of the EGF receptor in pancreatic beta cell growth and differentiation
Timo Otonkoski - Biomedicum Stem Cel Center and Children’s Hospital, University of Helsinki, Helsinki,
Finland
08h35 – 09h00 - Beta cel neogenesis in the postnatal pancreas
Luc Bouwens, Cel Differentiation Lab, Vrije Universiteit Brussel (Free University Brussels), Brussels,
Belgium.
09h10 – 09h35 - Regulation of beta cel mass: lessons from pregnancy and birth –
Jens Høiriis Nielsen, Department of Biomedical Sciences, University of Copenhagen, Denmark
09h45 – 10h00 - Coffee break

10h00 – 11h45 - Lectures
6 - Islet pathophysiology in diabetes
Chairs Decio Eizirik; Lício Vel oso
10h00 – 10h25- Peroxisomal stress and the role of free radicals in β-cel lipotoxicity –
Sigurd Lenzen - Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
10h35 – 11h00 - Molecular mechanisms of lipotoxic beta cel demise –
Miriam Cnop – Université Libre de Bruxelles (ULB), Brussels, Belgium
11h10 – 11h35 - The binary switch between life and death of ER stressed beta cel s –Fumihiko Urano –
University of Massachusetts Medical School, USA
11h45 – 12h00 - Closing remarks
Chair – Anders Tengholrn
12h00 – 12h00 Assembly of the ISG Society
Departure

Source: http://www.eventus.com.br/islet2011/imagens/programa_ilhotas.pdf