Secondary hormonal manipulations in the treatment of castration refractory prostate cancer

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Design and end points of clinical trials for signaling in disease progression in CRPC has patients with progressive prostate cancer It is of interest that 31 of 37 patients had led to the development of newer drugs such as abiraterone and MDV 3100. Abiraterone acetate (Johnson & Johnson, New Brunswick, Clinical Trials Working Group. J Clin Oncol NJ), is an orally administered pregnenolone 2008; 26: 1148–59
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been misconstrued as suggestive of clinical enzyme in androgen synthesis) and blocks the benefit [4]. Therefore, the Prostate Cancer synthesis of androgens in the testes, adrenal Clinical Trials Working Group 2 (PCWG2) has glands and prostate, without causing adrenal insufficiency [1]. MDV 3100 (Medivation Inc, The Lancet Oncology 2009; 10:
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in androgen synthesis and has been widely expected in near future. Until more promising used in combination with hydrocortisone for ketoconazole remains a pertinent option in ketoconazole is associated with significant patients with CRPC when clinical trials are not independent prostate cancer. Cancer toxicities. The effect of ketoconazole on 2006; 107: 975–81
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