10445-07

Modern methods of oral treatment of erectile dysfunction Stefancik J, Novotny V, Trebaticky B, Breza J Department of Urology, Faculty of Medicine, Comenius University, Derer’s Memorial Hospital, Bratislava, [email protected] Erectile dysfunction (ED) is defined as a temporary or permanent inability to obtain or maintain erec- tion sufficient for satisfactory sexual intercourse. ED is not considered to be a genuine disease, it is rather a symptom accompanying other systemic diseases. Almost 52 per cent of men claim erectile dysfunction of different degree, however, only 5–10 per cent of them would confirm their handicap.
Key words: erectile dysfunction, sexual life, oral treatment of erectile dysfunction.
Erectile dysfunction (ED) is defined as a temporary or per- the paraventricular and preoptic nuclei of the hypothalamus manent inability to obtain or maintain erection sufficient for (apomorphin – Uprima) or peripherally in the corpora cavernosa satisfactory sexual intercourse. ED is not considered to be by inhibiting the enzyme phosphodiesterase-5 (sildenafil – a genuine disease, it is rather a symptom accompanying other Viagra, tadalafil – Cialis, vardenafil – Levitra). Thus, meta- systemic diseases. Almost 52 per cent of men claim erectile bolic degradation of cyclic guanosine-monophosphate, catabo- dysfunction of different degree, however, only 5 – 10 per cent lized by PDE-5, is blocked, cGMP can accumulate in cavernosal of them would admit their handicap. The value of sexual life in smooth muscle cells and upon sexual stimulation lead to devel- the scale of other human life values is high, just behind the opment of erection. The efficacy of all PDE-5 inhibitors is com- values of health, love, friendship and children, however, it is parable, they differ from each other in the duration of action considered to be much more important than money or profes- and incidence and severity of side effects.
sional success. Identification of men suffering from erectiledysfunction is of extraordinary importance also because of the fact that erectile dysfunction may be the first sign of oth- erwise asymptomatic severe system diseases such as hyper- tension, diabetes mellitus, coronary heart disease or certainmalignant diseases.
Erectile dysfunction influences significantly men’s self es- teem, relationship with their partners, may lead to significant personal problems, depression and social isolation.
The choice of most appropriate ED treatment depends on several factors: on ED etiopathogenesis, personal preferences,patient’s age, comorbidity, religious and ethnic aspects. Therapy of ED must at the same time fulfil some medical criteria. It Department of Urology, Faculty of Medicine, Comenius University, must be simple, non-invasive, painless, highly efficient with minimum negative adverse events. Oral treatment of ED fulfils Address for correspondence: J. Stefancik, MD, Dept of Urology, Fa- all of these criteria and, at present, it is considered the gold culty of Medicine, Comenius University, Derer’s Memorial Hospital, standard and for majority of patients with ED it is the first choice Limbova 5, SK-833 05 Bratislava 37, Slovakia.
of treatment. The drugs utilized in oral treatment of ED act This report was presented on the Meeting of Slovak Medical Society in either centrally by stimulating the dopaminergic receptors in

Source: http://www.bmj.sk/2003/10445-07.pdf