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NEW IMPROVED SERRAPEPTASE FORMULA
SerraPlus+™ Mega Tabs with MSM and 73 Trace Minerals
This fabulous new formula provides double strength 40,000iu enteric coated tablets for thebest absorption, as well as the inclusion of 73 Trace Minerals (50mg) to ensure BETTERutilization of the enzymes. The combination of 350mg of MSM for joint, skin, and connectivetissue repair makes this more than doubly effective than just a 20,000iu Serrapeptase tablet.
Serrapeptase: 400mg enteric coated, giving 40,000iu of activity, makes this the mostpowerful delivery of serrapeptase available on the market at the lowest cost.
73 Trace Minerals: 50mg delivers potent organic minerals missing from the food chain toensure better activation of enzymes.
MSM: 350mg of this organic sulphur ensure support for joints, skin, and connective tissue. The simple answer is: Serrapeptase is the best anti-inflammatory enzyme available. It doesNOT affect any drugs whatsoever, except to the point that it may make them unnecessary. Read on for more Information on Serrapeptase The following is extracted from "The 2nd Gift from Silkworm is Serrapeptase" for educationalpurposes. The Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaqueand inflammation in all forms. The late German physici, usedSerrapeptase to treat arterial blockage in his coronary patients. Serrapeptase protectsagainst stroke and is reportedly more effective and quicker than EDTA Chelation treatmentsin removing arterial plaque. He also reports that Serrapeptase dissolves blood clots andcauses varicose veins to shrink or diminish. Dr. Nieper told of a woman scheduled for handamputation and a man scheduled for bypass surgery who both recovered quickly withoutsurgery after treatment with Serrapeptase.
SerraPlus+™ (Serrapeptase) has wide clinical use spanning over twenty-five yearsthroughout Europe and Asia as a viable alternative to salicylates, ibuprofen and the morepotent NSAIDs. Unlike these drugs, SerraZyme is a naturally occurring, physiologic agentwith no inhibitory effects on prostaglandins and is devoid of gastrointestinal side effects.
SerraPlus+™ is a proteolytic enzyme isolated from the micro-organism, Serratia E15. Thisenzyme is naturally present in the silkworm intestine and is processed commercially todaythrough fermentation. This immunologically active enzyme is completely bound to the alpha 2macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effectsof this naturally occurring enzyme.
Indications shown in various studies and reported by Practitioners on their patients: Pain of any kind. Arthritis, MS, (Multiple Sclerosis), Rheumatoid Arthritis and Lupus etc. Headaches and Migraines caused by inflammation. Lungs - Emphysema, Bronchitis, Pulmonary Tuberculosis, Bronchial Asthma, Bronchiectasisetc Eye Problems from inflammation or blocked veins etc. Sinusitis problems, chronic ear infections and runny nose etc Sports Injuries, traumatic swelling, post operative swellings and leg ulcers that are nothealing. Inflammation of any kind: inflammatory bowls diseases-, (Crohn’s, Colitis etc) Cystitis etc andin joints or muscles e.g. Fibromyalgia Breast Engorgement, Fibrocystic Breast Disease etc Cardiovascular Disease and Varicose Veins etc The main question we are asked is: “Will this conflict with any drugs I am taking or cause my blood to become to thin?” Answer:There are many opinions about what to take with what and what is a so called 'blood thinner'.
Firstly Aspirin is NOT a blood thinner such as W arfarin. Aspirin is an anti-inflammatory as areall proteolytic enzymes. They cause the blood to flow normally, not thinner than normal bystopping the inflammation in the blood stream that causes blood clotting.
The prime cause of western diseases is now considered to be chronic inflammation causedby eating starchy carbohydrates, processed, micro-waved and generally overcooked foods.
This is measured by the rise in C-Reactive proteins after eating such foods. When we havechronic inflammation as well as free radical damage, we get what is known as sticky blood,where the platelets stick together and can clot.
Any method of anti-inflammatory action would cause the blood to thin when the blood cellsstop being sticky.
Even just eating salad or raw vegetables would cause the same action as Aspirin orWarfarin. I have yet to see Doctors telling people not to eat too much salad when they aretaking W arfarin (but who knows what they may say next?).
It could even be taken even if you had nothing wrong whatsoever (inflammation also beingthe cause of premature ageing).
A Potent Proteolytic Enzyme The inflammatory response is an important mechanism for protecting the body from attack byinvading organisms and faulty cells. In the case of immune dis-regulation, the body loses itsability to differentiate between innocuous and potentially dangerous substances. Thisdefective mechanisms results in a wide array of autoimmune diseases such as allergies,psoriasis, rheumatoid arthritis, ulcerative colitis, uveitis, multiple sclerosis and some forms ofcancer.
Standard drug therapy for inflammatory-mediated diseases and trauma include steroids andnon-steroidal anti-inflammatory agents (NSAIDs). Both classes of drugs offer temporary,symptomatic relief from swelling, inflammation and accompanying pain without treating theunderlying condition. These drugs may also be immunosuppressive and cause dangerousside effects. The conscientious physician must weigh the benefits and long-term risksassociated with the use of NSAIDs, especially in cases of rheumatoid arthritis. If leftuntreated, the inflammatory process itself can lead to limitation of joint function anddestruction of bone, cartilage and articular structures.
NSAIDs are among the most widely prescribed drugs for rheumatoid arthritis and otherinflammatory joint conditions. Their effects are mediated through inhibition of thebiosynthesis of prostaglandins. They work by irreversibly blocking cyclooxygenase, theenzyme which catalyses the reactions of arachidonic acid to endoperoxide compounds. Theneurological and gastrointestinal side effects of these agents have been reviewed inconsiderable detail. All of the NSAIDs, with the exception of Cytotec, inhibit prostaglandin El,a local hormone responsible for gastric mucosai cytoprotection. A common side effect fromthese medications is gastric ulcers. More serious adverse reactions such as blooddyscrasias, kidney damage and cardiovascular effects have been noted. Most physiciansrotate among the ten most widely prescribed NSAIDs, as soon as one causes side effects orstops working.
The search for a physiologic agent that offers anti-inflammatory properties without causingside effects may have ended with the discovery of the Serratia peptidase (SP) enzyme. Thisanti-inflammatory agent is in wide clinical use throughout Europe and Asia as a viablealternative to salicylates, ibuprofen (sold as an OTC in the U.S.) and the more potentNSAIDs. Unlike these drugs, SP is a naturally occurring, physiologic agent with no inhibitoryeffects on prostaglandins and devoid of gastrointestinal side effects.
SP is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia El5.
This enzyme is naturally present in the silkworm intestine and is processed commerciallytoday through fermentation. This immunologically active enzyme is completely bound to thealpha 2 macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatoryeffects of this naturally occurring enzyme.
The silkworm has a symbiotic relationship with the Serratia microorganisms in its intestines.
The enzymes secreted by the bacteria in silkworm intestines have a specific affinity to avitaltissue and have no detrimental effect on the host's living cells. By dissolving a small hole inthe ~ silkworm's protective cocoon (avital tissue), the winged creature is able to emerge andfly away. The discovery of this unique biological phenomenon led researchers to studyclinical applications of the SP enzyme in man. In addition to its widespread use in arthritis,fibrocystic breast disease and carpal tunnel syndrome, researchers in Germany have usedSP for atherosclerosis. SP helps to digest atherosclerotic plaque without harming the healthycells lining Z the arterial wall. Today, researchers consider atherosclerosis an inflammatorycondition similar to other degenerative diseases. Some immunologists are even categorizingatherosclerosis as a benign tumour. Hardening and narrowing of the arterial wall is acumulative result of microscopic trauma; inflammation occurs in the presence of oxidizedlipids. SP doesn't interfere with the synthesis of cholesterol in the body, but helps clear avitaltissue from the arterial wall. It is important to note that cholesterol in its pure state is anantioxidant and a necessary component of the major organ systems in the body. The use ofmedications, which block cholesterol biosynthesis, may eventually damage the liver andcompromise anti-oxidant status of the eyes, lungs and other soft tissues.
While studies with SP in the treatment of coronary artery disease are relatively new, a wealthof information exists regarding its anti-inflammatory properties. SP has been used as an anti-inflammatory agent in the treatment of chronic sinusitis, to improve the elimination ofbronchopulmonary secretions, traumatic injury (e.g. sprains and torn ligaments), post-operative inflammation and to facilitate the therapeutic effect of antibiotics in the treatment ofinfections. In the urological field, SP has been used successfully for cystitis and epididymitis.
SP has been admitted as a standard treatment Germany and other European countries forthe treatment of inflammatory and traumatic swellings. In one double-blind study of SPconducted by Esch et al at the German State Hospital in UIm, 66 patients with fresh ruptureof the lateral ligament treated surgically were divided in three randomised groups. In thegroup receiving the test substance, the swelling had decreased by 50% on the third post-operative day, while in the other two control groups (elevation of the leg, bed rest, with orwithout the application of ice), no reduction in swelling had occurred at that time. Thedifference was of major statistical significance. Decreasing pain correlated for the most partwith the reduction in swelling. The patients receiving SP became pain-free more rapidly thanthe control groups. By the 10th day, all patients were free of pain in the SP-treated group.
The therapeutic daily dose was 1-2 tablets (5 mg) 3 times daily. In another double-blindstudy, the anti-inflammatory enzyme, SP, was evaluated in a group of 70 patients withevidence of cystic breast disease. These patients were randomly divided into a treatmentgroup and a placebo group. SP was noted to be superior to placebo for improvement ofbreast pain, breast swelling and induration with 85.7% of the patients receiving SP reportingmoderate to marked improvement. No adverse reactions were reported with the use of SP.
The use of enzymes with fibrinolytic, proteolytic and anti-edemic activities for the treatment ofinflammatory conditions of the ear, nose and throat has gained increasing support in recentyears.
In a third double-blind study, 193 subjects suffering from acute or chronic ear, nose or throatdisorders were evaluated. Treatment with SP lasted 7-8 days, two 5 mg tabs, t.i.d. After 3-4days treatment, significant symptom regression was observed in the SP-treated group, whilethis was not noted in the control group. Patients suffering from laryngitis, catarrhalrhinopharyngitis and sinusitis noted markedly rapid improvement. The physicians'assessments of efficacy of treatment were excellent or good for 97.3% of patients treatedwith SP compared with only 21.9% of those treated with placebo. In a similar study of chronicbronchitis, conducted by a team of otolaryngolosits, the SP-treated group showed excellentresults compared with the placebo group in the improvement of loosening sputum, frequencyof cough and expectoration. Other improvements included the posterior nasal hydro rheaand rhinos enosis. The administration of SP reduces the viscosity of the nasal mucus to alevel at which maximal transport can be achieved. It has also been demonstrated that thesimultaneous use of the peptidase and an antibiotic results in increased concentrations ofthe antibiotic at the site of the infection. The mechanisms of action of SP, at the sites of various inflammatory processes consistfundamentally of a reduction of the exudative phenomena and an inhibition of the release ofthe inflammatory mediators. This peptidase induces fragmentation of fibrinose aggregatesand reduces the viscosity of exudates, thus facilitating drainage of these products of theinflammatory response and thereby promoting the tissue repair process. Studies suggest thatSP has a modulatory effect on specific acute phase proteins that are involved in theinflammatory process. This is substantiated by a report of significant reductions in C3 and C4complement, increases in opsonizing protein and reductions in concentrations ofhaptoglobulin, which is a scavenger protein that inhibits lysosomal protease. Carpal tunnelsyndrome is a form of musculol-igamentous strain caused by repetitive motion injury.
Individuals who work at keyboard terminals are particularly susceptible to this condition.
While surgery has been considered the first line treatment for carpal tunnel syndrome, recentstudies reveal that the use of anti-inflammatory enzymes (e.g. SP and bromelain) inconjunction with vitamins B2 and B6 are also effective. The use of non-invasive, nutritionalapproaches to the treatment of this common condition will become more important as ageneration of keyboard operators approach retirement. Several research groups havereported the intestinal absorption of SP. SP is well absorbed orally when formulated with anenteric coating. It is known that proteases and peptidases are only absorbed in the intestinalarea. These enzymes are mobilized directly to the blood and are not easily detectible inurine. Other enzymes with structural similarities have been reported to be absorbed throughthe intestinal tract. Chymotrypsin is transported into the blood from the intestinal lumen.
Horseradish peroxidase can cross the mucosal barrier of the intestine in a biologically andimmunologically active form. Several studies have appeared so far which refer to thesystemic effects of orally given proteases and peptidases (e.g. SP), such as repression ofoedema and repression of blood vessel permeability induced by histamine or bradykinin.
These enzymes also affect the kallikrein-kinin system and the complement system, thusmodifying the inflammatory response. In vitro and in vivo studies reveal that SP has aspecific, anti-inflammatory effect, superior to that of other proteolytic enzymes. A review ofthe scientific literature, including a series of controlled, clinical trials with large patient groups,suggests that Serrapeptase is useful for a broad range of inflammatory conditions. If oneconsiders the fact that anti-inflammatory agents are among the most widely prescribeddrugs, the use of a safe, proteolytic enzyme such as SP would be a welcome addition to thephysician's armamentarium of physiologic agents. The simple answer is serrapeptase is the best anti-inflammatory enzyme available. It doesNOT affect any drugs whatsoever except that it may make them unnecessary.

Source: http://www.backtowork.co.uk/docs/SerraPlusInfo01.pdf