Safety data sheet

SIGMA-ALDRICH
sigma-aldrich.com
Material Safety Data Sheet

1. PRODUCT AND COMPANY IDENTIFICATION
3050 Spruce Street SAINT LOUIS MO 63103 USA both supplier and manufacturer) Preparation Information Product Safety - Americas Region 1-800-521-8956
2. HAZARDS IDENTIFICATION
Emergency Overview
OSHA Hazards
Harmful by ingestion.
GHS Classification
Acute toxicity, Oral (Category 4)
Acute toxicity, Dermal (Category 5)
Acute aquatic toxicity (Category 2)
GHS Label elements, including precautionary statements
HMIS Classification
Health hazard:
Flammability:
Physical hazards:
NFPA Rating
Health hazard:
Reactivity Hazard:
Potential Health Effects
Inhalation
May be harmful if inhaled. May cause respiratory tract irritation. Sigma - R2625
Harmful if absorbed through skin. May cause skin irritation. Ingestion

3. COMPOSITION/INFORMATION ON INGREDIENTS
Vitamin A acid all-trans-Retinoic acid Tretinoin Tretinoin

4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

5. FIREFIGHTING MEASURES
Conditions of flammability
Not flammable or combustible.
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Hazardous combustion products
Hazardous decomposition products formed under fire conditions. - Carbon oxides

6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Avoid breathing dust.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment
must be avoided.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for
disposal.

7. HANDLING AND STORAGE
Sigma - R2625
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: -20 °C
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Contains no substances with occupational exposure limit values. Personal protective equipment
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection
use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components
tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching
glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in
accordance with applicable laws and good laboratory practices. Wash and dry hands.
Eye protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of
workday.

9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Safety data
Melting point/range: 180 - 181 °C (356 - 358 °F) - lit. Sigma - R2625

10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
Light.
Materials to avoid
Oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION
Acute toxicity
Oral LD50
LD50 Oral - rat - 2,000 mg/kg
Inhalation LC50
no data available
Dermal LD50
LD50 Dermal - rabbit - > 2,500 mg/kg
Other information on acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
Eyes - rabbit - No eye irritation
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
negative
Carcinogenicity
No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. No component of this product present at levels greater than or equal to 0.1% is identified as a Sigma - R2625
carcinogen or potential carcinogen by OSHA. Reproductive toxicity
Teratogenicity
Specific target organ toxicity - single exposure (Globally Harmonized System)
no data available
Specific target organ toxicity - repeated exposure (Globally Harmonized System)
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
May be harmful if inhaled. May cause respiratory tract irritation. Ingestion
Harmful if absorbed through skin. May cause skin irritation. Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Synergistic effects
no data available
Additional Information
RTECS: VH6475000

12. ECOLOGICAL INFORMATION
Toxicity
LC50 - Danio rerio (zebra fish) - 4.64 mg/l - 96 h Persistence and degradability
Result: > 60 % - Readily biodegradable. Bioaccumulative potential
Does not bioaccumulate.
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
13. DISPOSAL CONSIDERATIONS
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Sigma - R2625
Contaminated packaging
Dispose of as unused product.

14. TRANSPORT INFORMATION
DOT (US)
IMDG
IATA

15. REGULATORY INFORMATION
OSHA Hazards
Harmful by ingestion.
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold
(De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Acute Health Hazard
Massachusetts Right To Know Components
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components
New Jersey Right To Know Components
California Prop. 65 Components
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other
reproductive harm.

16. OTHER INFORMATION
Further information
Copyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or
from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for
additional terms and conditions of sale.
Sigma - R2625

Source: http://apps.wku.edu/sds/uploads/docs/8465.pdf