Do you have problems calming down a restless mind? Dr. Daniel Amen, New York Times bestselling author of “Magnificent Mind at Any Age” and “Healing Anxiety and Depression” has developed NeuroGABA, a combination of inhibitory neurotransmitters vital to quieting an overactive brain. We recommend NeuroGABA for those individuals who are predisposed towards excessive worry and anxiety. If you are experiencing issues with nervousness and feelings of restlessness your brain might be overexcited, which can lead to irritability, tension, poor concentration and insomnia. If you are seeking a healthy, non-addictive means to address these issues, then NeuroGABA might be right for you. This supplement works to relax the central nervous system, thereby bringing an overall sense of calm and balance back to the body and brain. Background GABA or gamma-aminobutyric acid is an amino acid that regulates brain excitability and GABA supplements are recommended for the treatment of anxiety and stress. GABA and GABA enhancers such as the anticonvulsant gabapentin, L-theanine (found in green tea) and ethanol (alcohol) function to inhibit the excessive firing of neurons which results in a feeling of calm. Low levels of GABA have been found in many psychiatric and neurological disorders including depression, schizophrenia and Alzheimer’s disease (Ref. 10,13-15). While clinical studies using GABA supplements are still limited (see below), studies using medications that enhance GABA, such as lorazepam and gabapentin, have been proven to effectively treat panic disorders, epilepsy and insomnia (Ref. 3,5,6,11,16). There is some question as to how easily GABA crosses the blood brain barrier, but evidence in the literature supports its efficacy. In addition, natural GABA supplements have not been shown to have side effects. We recommend one to three capsules of NeuroGABA 750 a day. Glycine is also an inhibitory neurotransmitter, which means it calms brain activity. It is an important protein in the brain as it serves as a building block for DNA synthesis. Recent studies have demonstrated its effectiveness in the treatment of obsessive- compulsive disorder (Ref. 1) schizophrenia (Ref. 8) and in reducing neuropathic pain (Ref. 2). Scientific Studies Dr. Abdou and his colleagues have reported that oral supplementation of GABA has been shown to increase alpha wave activity in the brain, which occurs when one is awake and in a relaxed state. These findings support the use of GABA for relaxation, stress reduction, and improved concentration (Ref. 4). GABA has also been shown to reduce blood pressure (Ref. 7) and is important in making brain connections (Ref. 9). Recommended Use:
For children, 50 to 100 pounds consult your health care practitioner. Over 100 pounds or an adult, use 1 to 3 capsules dissolved in water daily.
Caution: Use GABA according to your weight and age. Servings per container: 60 Each capsule contains:
GABA (as gamma-aminobutyric acid) 750mg
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References:
1. Dohi, T., et al. (2009) Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain Pharmacol Ther April 23 (Epub ahead of print).
2. Greenberg, WM., et al. (2009) Adjunctive glycine in the treatment of obsessive-compulsive disorder in adults J Psychiatr Res 6:664-70.
3. Menzies, L., et al. (2007) Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia Arch Gen Psychiatry 2:156-67.
4. Abdou, A., et al. (2006) Relaxation and immunity enhancement effects of g-Aminobutyric acid (GABA) administration in humans BioFactors 3:201-8.
5. Spila B., (2006) Gabapentin (GBP) in panic disorders-case report Psychiatr Pol 40:1061-1068.
6. Bazil CW., (2005) Gabapentin improves sleep in the presence of alcohol J Clin SleepMed 1:284-287.
7. Hayakawa K., et al. (2004) Effect of gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats British J of Nutrition 92:411-417.
8. Heresco-Levy, U., et al. (1999) Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia Arch Gen Psychiatry 1:29-36.
9. Belhage, B., et al. (1998) Effects of gamma-aminobutyric acid (GABA) on synaptogenesis and synaptic function Perspect Dev Neurobiol 2-3:235-46.
10. Petty F, (1994) Plasma concentrations of gamma-aminobutyric acid (GABA) and mood disorders: a blood test for manic depressive disease? Clin Chem 2:296-302.
11. Breslow, M., et al. (1989) Role of gamma-aminobutyric acid in antipanic drug efficacy Am J Psychiatry 3:353-6.
12. Enna SJ, (1984) The Role of gamma-aminobutyric acid in anxiety Psychopathology Suppl 1:15-24.
13. Kasa K., et al. (1982) Cerebrospinal fluid gamma-aminobutyric acid and homovanillic acid in depressive disorders Biol Psychiatry 8:877-83.
14. Zimmer R, et al. (1984)Gamma-aminobutyric acid and homovanillic acid concentration in the CSF of patients with senile dementia of Alzheimer’s type Arch Neurol 6:602-4. 15. Perry T., et al. (1979) Gamma-aminobutyric-acid deficiency in brain of schizophrenic patients Lancet 1(8110):237-9. 16. Cross, AJ., et al. (1979) Gamma-aminobutyric acid in the brain in schizophrenia Lancet 1(8115):560-1.
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